Results 41 to 50 of about 10,149,535 (194)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Experimental Study to Determine the Development of Axial Stiffness of Wood Screws with Increasing Load Cycles

open access: yesBuildings
123 withdrawal tests were conducted to investigate the change in axial stiffness of fully threaded screws under axial loading and up to four loading cycles.
Sebastian Egner, Philipp Dietsch
doaj   +1 more source

Influence of duration and frequency of load application on the stress-strain state of the track

open access: yesВестник Научно-исследовательского института железнодорожного транспорта, 2018
. In 2014–2016 on the Kovdor—Pinozero section of Oktyabrskaya Railway tests were carried out on the impact of cars with axial loads of 245.3 and 264.9 kN on the track in comparison with standard cars with an axial load of 230.5 kN.
M. M. Zheleznov   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Farklı Beton Dayanımlarındaki Kolonlarda, Eksenel Yük Seviyelerine Göre Geri Sıçramalı Çekiç Verilerinin Korelasyonu İçin Deneysel Bir Öneri

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Betonun basınç dayanımı, betonarme sistemin yapısal bütünlüğü açısından hayati önem taşımaktadır. Gerek inşaat aşamasında gerekse inşaat tamamlandıktan sonra, farklı yapı elemanlarındaki basınç dayanımlarının bilinmesi, kontrol ve değerlendirme ...
Yusuf Demirel
doaj  

Experimental Study on the Negative Skin Friction of the Pile Group Induced by Rising and Lowering the Groundwater Level

open access: yesAdvances in Civil Engineering, 2021
Negative skin friction (NSF) has been one of the important factors in the design of pile foundation; especially, the influence of water level on the pile negative skin friction should be paid attention. In this paper, a series of model tests were carried
Yu Zhang   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Effect of General Imperfections on the Buckling of Cylindrical SheIls. [PDF]

open access: yes, 1968
An experimental and theoretical investigation of the effect of general imperfections on the buckling load of a circular cylindrical shell under axial compression was carried out.
Arbocz, Johann
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Improved SDOF Approach to Incorporate the Effects of Axial Loads on the Dynamic Responses of Steel Columns Subjected to Blast Loads

open access: yesAdvances in Civil Engineering, 2019
In this paper, a complicated single-degree-of-freedom (SDOF) approach was developed to determine the global response of steel columns under combined axial and blast-induced transverse loads.
Junbo Yan, Yan Liu, Fenglei Huang
doaj   +1 more source

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