Results 61 to 70 of about 10,149,535 (194)

Exploratory Biomechanical Comparison of Three Posterior Pelvic Ring Fixation Strategies in a Standardized Tile C1.2 Synthetic Model

Diagnostics
Background: Tile C1.2 pelvic ring injuries are characterized by combined rotational and vertical instability and require reliable posterior stabilization.
Adrian Claudiu Carp, Awad Dmour, Radu Ștefănoiu, Nicolae Șerban, Mihnea-Theodor Sîrbu, Bogdan Puha, Norin Forna, Liliana Savin, Alexandru Filip, Dragoș-Cristian Popescu, Paul-Dan Sîrbu, Bogdan Veliceasa   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Elastic-plastic behaviour of AISiC metal matrix composite rod under combined tension and torsion loading [PDF]

, 2003
Most machine components and structural members are subjected to complex loading conditions during service. Typical complex loading conditions can be observed in the case of a bolt When a bolt is tightened to bring machine components together, stresses ...
Raghupathy, Padmanabhan
core   +2 more sources

The behavior of ultra-high-strength reinforced concrete columns under axial and cyclic lateral loads

HBRC Journal, 2016
In general Ultra High Strength Concrete (UHSC) is a new class of concrete that has been developed in recent decades. UHSC is characterized by extraordinary mechanical and durability properties. The UHSC-Matrix is very brittle material behavior.
Mohamed M. EL-Attar, Hossam Z. El-Karmoty, Amal A. EL-Moneim   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Use of Pile Driving Analysis for Assessment of Axial Load Capacity of Piles [PDF]

, 2012
Driven piles are commonly used in foundation engineering. Pile driving formulae, which directly relate the pile set per blow to the capacity of the pile, are commonly used to decide whether an installed pile will have the designed capacity.
Salgado, Rodrigo, Zhang, Yanbei
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Quantification of differential axial shortening in reinforced concrete and concrete-filled steel-tube-based building structures

Journal of Asian Architecture and Building Engineering
This paper compares the axial shortening behaviors of reinforced concrete (RC) and concrete-filled tube (CFT) columns in high-rise building structures and proposes a relationship between the differential axial shortening and the dead load portion.
SeongHun Kim, Hyo-Gyoung Kwak
doaj   +1 more source

Drift capacity and allowable axial load level of RC columns

, 2023
© 2023 Institution of Structural EngineersIn this study, a new model is developed to estimate lateral deformation capacity or drift ratio of RC columns. This new model is applicable to all columns having greater shear capacity than demand.
Eser Aydemir, Müberra, Müberra Eser Aydemir, Cem Aydemir, Güray Arslan, Aydemir, Cem, ARSLAN, Güray   +5 more
core   +1 more source