Results 81 to 90 of about 10,149,535 (194)

Unveiling Axial Load Transfer Mechanism in Fully Encapsulated Rock Bolts [PDF]

Determining the axial load transfer mechanism of rock bolts under various conditions is paramount for ensuring efficient reinforcement in rock structures, advancing our understanding of rock support and ability to design robust engineering solutions ...
Craig, Peter, Aziz, Naj, Mirzaghorbanali, Ali, Rastegarmanesh, Ashakan, McDougall, Kevin, Nourizadeh, Hadi, Mitri, Hani   +6 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Impact on railway track of cars with increased axle load

Вестник Научно-исследовательского института железнодорожного транспорта, 2016
Solving the problem of development of growing volume of traffic in the absence of reserves of available and actual capacity on a number of areas and entire directions necessitates continuous increase of train weight, as well as the use of cars with ...
V. V. Tret’Yakov, I. B. Petropavlovskaya, V. O. Pevzner, T. I. Gromova, I. V. Tret’Yakov, K. V. Shapet’Ko, I. S. Smelyanskaya, A. S. Tomilenko   +7 more
doaj   +1 more source

Influence of Imperfections on Axial Buckling Load of Composite Cylindrical Shells [PDF]

, 2013
There is a strong requirement for more robust, lighter and cheaper launch vehicle structures. Unstiffened composite cylindrical shells, which are essential to the fabrication of launch vehicle airframes, are prone to buckling and are highly sensitive to ...
Prusty, G., Thomson, Rodney, Degenhardt, Richard, Keple, Jendi, Kelly, Don, Pearce, G.   +5 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Experimental and finite element study of the hydroforming bi-layered tubular components [PDF]

, 2005
The application of finite element method (FEM) in the area of metal forming and material processing has been increasing rapidly during the recent years.
Islam, Mohammad Din
core   +2 more sources

Development of a Physiologic In-Vitro Testing Methodology for Assessment of Cervical Spine Kinematics [PDF]

, 2013
In-vitro biomechanical testing has been critical in the design and evaluation of spinal surgical instrumentation, however determination of realistic physiologic loading levels has proven difficult outside of the in-vivo setting.
Bell, Kevin
core  

Behaviour and design of composite beams subjected to negative bending and compression [PDF]

, 2012
This paper investigates the behaviour of steel–concrete composite beams subjected to the combined effectsof negative bending and axial compression. For this study, six full-scale tests were conducted on compositebeams subjected to negative moment while ...
Uy, Brian (R9735), Vasdravellis, George; id_orcid, Kirkland, Brenadan, Uy, Brian, Vasdravellis, George (R16696), Tan, Ee Loon (R14425), Tan, Ee Loon, Kirkland, Brendan (S24876)   +7 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source