Results 91 to 100 of about 304,829 (369)
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status Scale (EDSS) scores, magnetic resonance imaging (MRI) lesion counts, and ...
Antonia Bralić +13 more
wiley +1 more source
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Science, 2015 Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation.
J. Ruschel +17 more
semanticscholar +1 more source
Metabolic Interaction Between Schwann Cells and Axons Under Physiological and Disease Conditions
Frontiers in Cellular Neuroscience, 2020 Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination ...
Filipa Bouçanova +3 more
doaj +1 more source
A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases [PDF]
, 2015 The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments align longitudinally in axons and are interspersed in axonal cross-sections.
arxiv +1 more source
The axonal transport of mitochondria [PDF]
Journal of Cell Science, 2005 Organelle transport is vital for the development and maintenance of axons, in which the distances between sites of organelle biogenesis, function, and recycling or degradation can be vast. Movement of mitochondria in axons can serve as a general model for how all organelles move: mitochondria are easy to identify, they move along both microtubule and ...
Peter J. Hollenbeck, William M. Saxton
openaire +5 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Sculpting neural circuits by axon and dendrite pruning.
Annual Review of Cell and Developmental Biology, 2015 The assembly of functional neural circuits requires the combined action of progressive and regressive events. Regressive events encompass a variety of inhibitory developmental processes, including axon and dendrite pruning, which facilitate the removal ...
Martin M. Riccomagno, A. Kolodkin
semanticscholar +1 more source
The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier
eLife, 2017 A high density of Na+ channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions between ...
Veronique Amor +8 more
doaj +1 more source
arXiv, 2003 What determines the caliber of axonal branches? We pursue the hypothesis that the axonal caliber has evolved to minimize signal propagation delays, while keeping arbor volume to a minimum. We show that for a general cost function the optimal diameters of mother ($d_0$) and daughter ($d_1$, $d_2$) branches at a bifurcation obey a branching law: $d_{0}^{\
arxiv
CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh +8 more
wiley +1 more source