Results 101 to 110 of about 479,230 (336)

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]

, 2016
Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E, Banna, Chris D, Low, Seng Hui, Radeke, Carolyn M, Sharma, Nikunj, Soo Hoo, Linda, Vandenberg, Carol A, Weimbs, Thomas   +7 more
core   +1 more source

Description and Evaluation of a Pharmacy Graduate Health Services Research Methods Course

Pharmacy
The purpose of this paper is to provide a description and evaluation of a graduate-level Health Services Research Methods course offered at the University of Arizona R. Ken Coit College of Pharmacy.
David R. Axon
doaj   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Viral Vector-based Improvement of Optic Nerve Regeneration: Characterization of Individual Axons\u27 Growth Patterns and Synaptogenesis in a Visual Target [PDF]

, 2015
Lack of axon growth ability in the central nervous system poses a major barrier to achieving functional connectivity after injury. Thus, a non-transgenic regenerative approach to reinnervating targets has important implications in clinical and research ...
Blackmore, Murray G., Luo, Xueting, Salgueiro, Yadira, Yungher, Benjamin J.   +3 more
core   +1 more source

A model of fasciculation and sorting in mixed populations of axons

, 2011
We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development.
D. ben Avraham, Debasish Chaudhuri, G. M. Shepherd, H. Kuhn, I. Rodrigues Iturbe, J. D. Murray, L. Crews, M. J. Katz, Martin Zapotocky, Peter Borowski, S. Redner, V. Kampen   +11 more
core   +1 more source

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Cell Death and Differentiation, 2014
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their ...
M. D. Stefano, I. Nascimento-Ferreira, G. Orsomando, Mori, J. Gilley, Rosalind Brown, Lucie Janeckova, M. E. Vargas, L. A. Worrell, Andrea Loreto, Joseph Tickle, Jane Patrick, Jamie R.M. Webster, Martina Marangoni, F. M. Carpi, Stefania Pucciarelli, Francesca Rossi, Weina Meng, A. Sagasti, R. Ribchester, Giulio Magni, M. Coleman, Laura Conforti   +22 more
semanticscholar   +1 more source

P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development

Frontiers in Cellular Neuroscience, 2019
Morphological and functional polarization of neurons depends on the generation and maintenance of the axon initial segment (AIS). This axonal domain maintains axonal properties but is also the place where the action potential (AP) is generated. All these
Wei Zhang, Angela Bonadiman, María Ciorraga, María José Benitez, María José Benitez, Juan José Garrido   +5 more
doaj   +1 more source

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes

, 2008
Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in ...
A. L. Hodgkin, A. V. Hill, B. Hille, D. J. Aidley, Ekrem Aydiner, P. Ghosh, Riza Erdem   +6 more
core   +1 more source

Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
core   +1 more source