Results 101 to 110 of about 304,829 (369)
Quantitative mapping of the per‐axon diffusion coefficients in brain white matter
Magnetic Resonance in Medicine, 2015 This article presents a simple method for estimating the effective diffusion coefficients parallel and perpendicular to the axons unconfounded by the intravoxel fiber orientation distribution.
Enrico Kaden, F. Kruggel, D. Alexander
semanticscholar +1 more source
STORMing towards a clear picture of the cytoskeleton in neurons
eLife, 2015 Super-resolution microscopy has shed new light on the formation of the actin-spectrin network in neurons.
Emerson Stewart, Kang Shen
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Analog-digital facilitations (ADFs) have been described in local excitatory brain circuits and correspond to a class of phenomena describing how subthreshold variations of the presynaptic membrane potential influence spike-evoked synaptic transmission ...
Mickaël Zbili +2 more
doaj +1 more source
Mechanical Behavior of Axonal Actin, Spectrin, and Their Periodic Structure: A Brief Review [PDF]
arXiv, 2021 Actin and spectrin are important constituents of axonal cytoskeleton. Periodic actin and spectrin structures are found in dendrites, initial segment of axon, and main axon. Actin and spectrin periodicity has been hypothesized to be manipulating the axon stability and mechanical behavior.
arxiv
Neuron, 2005 Proteoglycans are complex macromolecules with the potential for extraordinary diversity. Several recent studies have demonstrated important roles for heparan sulfate and chondroitin sulfate proteoglycans (HSPGs and CSPGs) in axon pathfinding and have linked HSPGs to specific signaling pathways.
Holt, Christine E, Dickson, Barry J
openaire +4 more sources
A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen +8 more
wiley +1 more source
KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini +24 more
wiley +1 more source
Hyper-viscoelastic 3D response of axons subjected to repeated tensile loads in brain white matter [PDF]
arXiv, 2022 A novel finite element method (FEM) is developed to study mechanical response of axons embedded in extra cellular matrix (ECM) when subjected to harmonic uniaxial stretch under purely non-affine kinematic boundary conditions. The proposed modeling approach combines hyper-elastic (such as Ogden model) and time/frequency domain viscoelastic constitutive ...
arxiv
The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans
Genetics, 2016 The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal processes during development. In the past two decades, great progress has been made in understanding the molecular basis of axon outgrowth and guidance.
A. Chisholm +3 more
semanticscholar +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source