Results 241 to 250 of about 434,135 (356)

Functional role for Cas cytoplasmic adaptor proteins during cortical axon pathfinding. [PDF]

PLoS Genet
Estep JA, Treptow AM, Rao PA, Williamson P, Wong W, Riccomagno MM.   +5 more
europepmc   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Interplay of axon regeneration genes and immune infiltration in spinal cord injury. [PDF]

J Transl Med
Xiang Z, Fang D, Gao D, Zhang Q, Zhang Y, Sun Y, Li L, Zhang X, Li J, Ding L.   +9 more
europepmc   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in <i>Drosophila</i> larvae. [PDF]

Elife
Takagi S, Takano S, Kubo T, Hashimoto Y, Morise S, Zeng X, Nose A.   +6 more
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Mitochondria delay action potential propagation. [PDF]

Commun Biol
Castelfranco AM, Alcami P.
europepmc   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Frontiers of optic nerve regeneration research: an analysis of the top 100 most influential articles in the field from 2005 to 2025. [PDF]

Front Neurosci
Saijilafu, Chen P, Ye L, Shen Y, Wang Q, Chen X, Chimedtseren C, Zhang J, Fang L, Xu R.   +9 more
europepmc   +1 more source

High-Quality Cell Capture Reveals Transcriptomic Changes After Single-Axon Injury of Mauthner Cells [PDF]

Zheng Song, Lin Zhu, Yueru Shen, Huaitong Yao, Cai Yuan, Lingyu Shi, Xinghan Chen, Along Han, Zi-Ang Zhao, Kun Qu, Bing Hu   +10 more
openalex   +1 more source