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Axon Resealing Following Transection Takes Longer in Central Axons Than in Peripheral Axons: Implications for Axonal Regeneration

Experimental Neurology, 2001
Injury to axons in the CNS leads to little regenerative repair and loss of function. Conversely, injury to axons in the PNS results in vigorous regrowth of severed axons, usually with restoration of function. This difference is generally attributed to a CNS environment that either cannot support or actively inhibits regeneration and/or a failure of CNS
Farid A.K.M. Ahmed   +2 more
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AXONAL REGENERATION

Biological Reviews, 1996
Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Axonal oscillations in developing mammalian nerve axons

Physical Review E, 2005
We study neuronal spike propagation in a developing myelinated axon in various stages of its development through detailed computational modeling. Recently, a form of bursting (axonal bursting), has been reported in axons in developing nerves in the absence of potassium channels.
Peter Jung, Shangyou Zeng
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Axon-to-axon transmission in tullidora (buckthorn) neuropathy

Experimental Neurology, 1984
Oral administration of ether extracts of the tullidora ( Karwinskia humboldtiana ) fruit, which contains an identified neurotoxin, produced flaccid hind limb paralysis in cats after a latency of 4 to 7 weeks. Acute experiments were conducted after the paralysis was evident. Spinal roots of lumbar and sacral segments were transected as close as possible
Arturo Hernández-Cruz   +1 more
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On the Universality of Axon P Systems

IEEE Transactions on Neural Networks and Learning Systems, 2015
Axon P systems are computing models with a linear structure in the sense that all nodes (i.e., computing units) are arranged one by one along the axon.
Xingyi Zhang, L. Pan, A. Paun
semanticscholar   +1 more source

Axon, “axoff”

Science Signaling, 2023
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell–driven myelin perturbation.
openaire   +2 more sources

Axonal degeneration and disorders of the axonal cytoskeleton

1995
Abstract This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding of Wallerian degeneration. It then considers the slowly evolving axonal degenerations in which alterations in neurofilament content ...
Edwin B. George   +3 more
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Dynamic Condition of Protein in Axons and Axon Terminals

1971
Radioautographic studies performed with labeled amino acids visualize the complexity of the dynamic state of protein in nerve endings. One protein fraction, at least, is replaced at a rate of 4% per day. On the one hand, the loss of used protein in presynaptic axon terminals seems to be balanced by the arrival of new migratory proteins, synthesized in ...
H. L. Koenig, B. Droz
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Axonal transport

2016
Axonal transport is a constitutive process that supplies the axon and axon terminal with materials required to maintain their structure and function. Most materials are supplied via three rate components termed the fast component, slow component a, and slow component b. Each of these delivers a distinct set of materials with distinct transport kinetics.
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Axonal Pathfinding

2009
Axon pathfinding is an important process in the development of the nervous system. Models have been developed which describe or attempt to explain various aspects of axon pathfinding, such as axon extension, axon turning, axon guidance, interactions between axons, retinotectal mapping, and the way in which guidance cue patterns are generated in the ...
Mortimer, D., Goodhill, G. J.
openaire   +2 more sources

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