Results 61 to 70 of about 434,135 (356)
INF2‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2‐related FSGS is typically resistant to immunotherapy yet rarely recurs after transplantation, and its associated neuropathy can mimic treatable immune‐mediated disorders such as ...
Chikashi Yano +27 more
wiley +1 more source
Optimization of the leak conductance in the squid giant axon
, 2010 We report on a theoretical study showing that the leak conductance density, $\GL$, in the squid giant axon appears to be optimal for the action potential firing frequency.
A. L. Hodgkin +7 more
core +1 more source
Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. [PDF]
, 2018 Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance ...
Estep, Jason A +5 more
core +2 more sources
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
The Indian Anaesthetists' Forum, 2014 Anaesthesia management for proximal femoral fractures of high risk patients with debilitating systemic co-morbidities is a challenging task. It is generally done under the effect of regional anaesthesia or general anaesthesia (GA), with systemic ...
T.V.S Gopal, K. Sriprakash, Dabesh Bhoi
doaj
Trust and distrust in contradictory information transmission
Applied Network Science, 2017 We analyse the problem of contradictory information distribution in networks of agents with positive and negative trust. The networks of interest are built by ranked agents with different epistemic attitudes. In this context, positive trust is a property
Giuseppe Primiero +3 more
doaj +1 more source
Epistola di Quinto Oppio proconsole ad Afrodisia
Axon, 2021 L’iscrizione contiene una lettera inviata dal proconsole romano Oppio ai magistrati, al Consiglio e al demos di Afrodisia. Il documento è databile all’85 a.C., ma l’iscrizione a noi pervenuta è una copia del II sec. d.C..
Ferraioli, Ferdinando
doaj +1 more source
Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. [PDF]
, 2018 During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to ...
Chen, Shih-Yu +6 more
core
Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles [PDF]
, 2003 Early neuronal scaffold development studies suggest that initial neurons and their axons serve as guides for later neurons and their processes. Although this arrangement might aid axon navigation, the specific consequence(s) of such interactions are ...
Bak-Maier, Magdalena, Fraser, Scott E.
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich +10 more
wiley +1 more source