Results 61 to 70 of about 304,829 (369)

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells

Frontiers in Molecular Neuroscience, 2017
The microtubule (MT)-associated protein Tau is a natively unfolded protein, involved in a number of neurodegenerative disorders, collectively called tauopathies, aggregating in neurofibrillary tangles (NFT). It is an open question how the conversion from
Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak, Antonino Cattaneo   +6 more
doaj   +1 more source

gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]

arXiv, 2021
Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv  

Neuronal Dynamics and Axonal Flow: Axonal Peristalsis [PDF]

Proceedings of the National Academy of Sciences, 1972
By time-lapse, phase-contrast cinemicrography of sensory nerve fibers of young mice, isolated with their originating spinal ganglia in nutrient solution, the postulated peristaltic surface drive of the cellulifugal propulsion of the semisolid axonal column at a rate of the order of 1 mm/day (1 μm/min) could be verified and quantitatively analyzed.
openaire   +3 more sources

Trust and distrust in contradictory information transmission

Applied Network Science, 2017
We analyse the problem of contradictory information distribution in networks of agents with positive and negative trust. The networks of interest are built by ranked agents with different epistemic attitudes. In this context, positive trust is a property
Giuseppe Primiero, Franco Raimondi, Michele Bottone, Jacopo Tagliabue   +3 more
doaj   +1 more source

The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling [PDF]

Frontiers in Molecular Neuroscience, 2018
In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-dependent mechanisms.
Ana Rita Costa, Rita Pinto-Costa, Rita Pinto-Costa, Mónica Mendes Sousa, Sara Castro Sousa   +4 more
openaire   +5 more sources

SARM1 activation triggers axon degeneration locally via NAD+ destruction

Science, 2015
SARM1-driven axon degeneration Axons, the long protrusions of nerve cells, are programmed to self-destruct under certain conditions that occur during development, stress, or disease states. Gerdts et al. outline a biochemical mechanism that controls such
Josiah Gerdts, E. Brace, Y. Sasaki, A. Diantonio, J. Milbrandt   +4 more
semanticscholar   +1 more source

Carcinogenesis in Ulcerative Colitis: Is Surveillance Worthwhile?

Canadian Journal of Gastroenterology, 1990
Observations that dysplastic epithelium predicts neoplastic change in the coli tic bowel have led to the adoption of surveillance policies in ulcerative colitis patients, usually involving colonoscopy irrespective of symptomatology.
ATR Axon
doaj   +1 more source

Ethical Issues in the Management of Helicobacter pylori Infection

Canadian Journal of Gastroenterology, 2003
Medical ethics are not absolute; they change according to social attitudes, technological advances and alterations in the doctor/patient relationship.
Anthony Axon
doaj   +1 more source

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Lysosomes are found in all neuronal domains, including the soma, axon, and dendrites. How neurons are transported in these domains, however, remains poorly understood.
G. Farías, Carlos M. A. Guardia, Raffaella De Pace, Dylan J. Britt, J. Bonifacino   +4 more
semanticscholar   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source