Results 81 to 90 of about 304,829 (369)
Axon guidance pathways and the control of gene expression
Developmental Dynamics, 2018 Axons need to be properly guided to their targets to form synaptic connections, and this requires interactions between highly conserved extracellular and transmembrane ligands and their cell surface receptors.
Samantha A Russell, G. Bashaw
semanticscholar +1 more source
The Indian Anaesthetists' Forum, 2014 Anaesthesia management for proximal femoral fractures of high risk patients with debilitating systemic co-morbidities is a challenging task. It is generally done under the effect of regional anaesthesia or general anaesthesia (GA), with systemic ...
T.V.S Gopal, K. Sriprakash, Dabesh Bhoi
doaj
Neuron Growth Output-Feedback Control by PDE Backstepping [PDF]
arXiv, 2022 Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the extracellular matrix, the network of extracellular macromolecules, and minerals that control the tubulin protein ...
arxiv
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier +8 more
wiley +1 more source
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
eLife, 2016 Overexpression of the NAD+ biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD+ or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure.
Y. Sasaki +4 more
semanticscholar +1 more source
The Journal of Cell Biology, 2006 ![Graphic][1] Movement of mitochondria (blue and green) does not correlate with axonal advance (yellow). Mitochondria and other cellular subunits are transported from the cell body of neurons toward the growth cone of axons via kinesin-based fast transport.
openaire +2 more sources
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi +6 more
wiley +1 more source
Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Autophagy maintains cellular homoeostasis by bulk or selective degradation of cytoplasmic components including organelles or protein aggregates. Its role in axon regeneration remains speculative.
Miao He +5 more
semanticscholar +1 more source
IEEE Open Journal of the Communications SocietyComputation offloading in Internet of Vehicles (IoV) networks is a promising technology for transferring computation-intensive and latency-sensitive tasks to mobile-edge computing (MEC) or cloud servers.
Khaled A. Alaghbari +5 more
doaj +1 more source
Action potential solitons and waves in axons [PDF]
arXiv, 2022 We show that the action potential signals generated inside axons are reaction-diffusion solitons or reaction-diffusion waves, refuting the Hodgkin and Huxley hypothesis that action potentials propagate along axons with an elastic wave mechanism. Reaction-diffusion action potential wavefronts and solitons annihilate at collision and boundaries of axons,
arxiv