Results 81 to 90 of about 57,333 (280)

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

An axon initial segment is required for temporal precision in action potential encoding by neuronal populations

, 2018
Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale ...
Dannemeyer, Melanie, Enderlein, Jörg, Feulner, Barbara, Gutnick, Michael J., Lazarov, Elinor, Neef, Andreas, Wolf, Fred   +6 more
core   +1 more source

Glial βii spectrin contributes to paranode formation and maintenance [PDF]

, 2018
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D., Chang, Kae Jiun, Dupree, Jeffrey L., Galiano, Mauricio Raul, Griggs, Ryan B., Huang, Claire Yu Mei, Liu, Yanhong, Rasband, Matthew N., Susuki, Keiichiro, Tsai, Chang Ru, Yermakov, Leonid M., Zhang, Chuansheng, Zollinger, Daniel R.   +12 more
core   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

Advanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul, Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory Timp   +8 more
wiley   +1 more source

Differential Trafficking of Transport Vesicles Contributes to the Localization of Dendritic Proteins

Cell Reports, 2012
In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown.
Sarmad Al-Bassam, Min Xu, Thomas J. Wandless, Don B. Arnold   +3 more
doaj   +1 more source

TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment [PDF]

The Journal of Neuroscience, 2019
Selective cargo transport into axons and dendrites over the microtubule network is essential for neuron polarization. The axon initial segment (AIS) separates the axon from the somatodendritic compartment and controls the microtubule-dependent transport into the axon.
Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad   +14 more
openaire   +5 more sources

In Situ Study of Resistive Switching in a Nitride‐Based Memristive Device

Advanced Functional Materials, EarlyView.
In situ TEM biasing experiment demonstrates the volatile I‐V characteristic of MIM lamella device. In situ STEM‐EELS Ti L2/L3 ratio maps provide direct evidence of the oxygen vacancies migrations under positive/negative electrical bias, which is critical for revealing the RS mechanism for the MIM lamella device.
Di Zhang, Rohan Dhall, Matthew M. Schneider, Cun Li, Chengyu Song, Sundar Kunwar, Hongyi Dou, Natanii R. Yazzie, Henry Tran, Daniel Appuing, Jim Ciston, Nicholas G. Cucciniello, Pinku Roy, Michael T. Pettes, John Watt, Winson Kuo, Haiyan Wang, Ye Cao, Rodney J. McCabe, Aiping Chen   +19 more
wiley   +1 more source

Modulation of axon excitable domains by astrocytes and microglia

Frontiers in Cellular Neuroscience
Neuronal communication depends on neuronal polarity and the integrity of axonal excitable domains, including the axon initial segment (AIS), nodes of Ranvier, and presynaptic terminals. In addition to the influence of neuronal input on their function and
Juan José Garrido, Juan José Garrido
doaj   +1 more source

Fast and reliable identification of axons, axon initial segments and dendrites with local field potential recording

Frontiers in Cellular Neuroscience, 2015
The axon initial segment (AIS) is an essential neuronal compartment. It is usually where action potentials are initiated. Recent studies demonstrated that the AIS is a plastic structure that can be regulated by neuronal activity and by the activation of ...
Anders Victor ePetersen, Emil Østergård Johansen, Jean-François ePerrier   +2 more
doaj   +1 more source

Transcriptional control of behaviour: engrailed knockout changes cockroach escape trajectories [PDF]

, 2009
The cerci of the cockroach are covered with identified sensory hairs that detect air movements. The sensory neurons that innervate these hairs synapse with giant interneurons in the terminal ganglion that in turn synapse with interneurons and leg motor ...
Bacon, Jonathan P, Blagburn, Jonathan M, Booth, David, Domenici, Paolo, Marie, Bruno   +4 more
core   +1 more source