A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons [PDF]
Frontiers in PharmacologyIntroductionDysfunction of axoplasmic transport is closely linked to depression. Baicalin, a major flavonoid in Scutellaria baicalensis, a well-known traditional Chinese medicine used in depression treatment, has demonstrated antidepressant-like effects ...
Shuaifei Lu +19 more
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Slow axoplasmic transport under scrutiny [PDF]
Biological Research, 2011 The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism.
Felipe A Court, Jaime Álvarez
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Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport. [PDF]
J Neurochem, 2023 The excitatory neurotransmitter glutamate has a role in neuronal migration and process elongation in the central nervous system (CNS). The effects of chronic glutamate hyperactivity on vesicular and protein transport within CNS neurons, that is ...
Lee P +7 more
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Advances in origin, evolution, and pathogenesis of optic disc drusen: A narrative review [PDF]
Indian Journal of OphthalmologyOptic disc drusen (ODD) is acellular calcified deposits found mainly in front of the lamina cribrosa within the optic nerve. It can cause chronic or acute vision loss.
Xiyuan Liu, Yan Yan
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AXOPLASMIC TRANSPORT IN THE CRAYFISH NERVE CORD [PDF]
Proceedings of the National Academy of Sciences, 1969 Axoplasmic proteins in the crayfish nerve cord were labeled by the incorporation of high specific activity 3 H-leucine that was injected into one of the abdominal ganglia. The labeled proteins moved caudad as a sharply defined peak at 1.1 mm/day.
Hugo L. Fernández, Peter F. Davison
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Jaime Alvarez and the case against slow axoplasmic transport: some epistemological reflections
Biological Research, 2001 The 'slow axoplasmic transport theory' has been the prevailing view over the last forty years in order to explain the metabolic maintenance of neuronal axons and nerve endings. A significant amount of evidence against this theoretic interpretation of the
ALEJANDRO SERANI-MERLO
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Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein. [PDF]
Journal of Cell Biology, 1975 Pharmacological evidence is presented for the involvement of microtubules in the process of fast axoplasmic transport. A quantitative measure of the inhibition of axoplasmic transport in an in vitro preparation of rat sciatic nerve is described.
James C. Paulson, William O. McClure
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Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging [PDF]
Materials Today BioNeuroanatomical tract tracers are important for studying axoplasmic transport and the complex interconnections of the nervous system. Though traditional fluorescent tracers are widely used, they have several prominent drawbacks when imaging, including ...
Xiaoqi Yang +10 more
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IMMUNOFLUORESCENT STUDIES ON TYROSINE HYDROXYLASE: APPLICATION FOR ITS AXOPLASMIC TRANSPORT
, 1977 Specific antiserum to bovine adrenal tyrosine hydroxylase (TH) was produced in rabbits, and applied to the immunofluorescent study of the enzyme. Specific immunofluorescence for the enzyme was observed in guinea pig and bovine adrenal medulla and locus ...
Ikuko Nagatsu +5 more
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Axoplasmic transport of a brain-specific soluble protein☆ [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975 The rate and extent of axoplasmic transport of the brain-specific soluble protein (14-3-2 protein) has been investigated in the avian visual system. 1-day-old chicks were injected monocularly with tritiated proline, Incorporation of the isotope into the 14-3-2 protein synthesized within the retina of the injected eye, as well as the appearance of the ...
Paul J. Marangos +3 more
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