Results 211 to 220 of about 5,363,495 (332)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

An Efficient Regeneration and Transient Transformation System for the Desert Halophyte <i>Halostachys caspica</i>. [PDF]

Plants (Basel)
Tan S, Li H, Yi K, Zhan C, Tulaerbieke A, Wang Y.   +5 more
europepmc   +1 more source

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source

Advances in N- and S-Heterocycles as c-Jun-N-Terminal Kinase 3 Inhibitors for Alzheimer's Disease Treatment. [PDF]

Drug Dev Res
Yadav P, Mishra D, Singh R.
europepmc   +1 more source

A Practical and Efficient Green Synthesis of β-Aminophosphoryl Compounds via the Aza-Michael Reaction in Water

, 2010
E. V. Matveeva, Pavel V. Petrovskii, Zinaida S. Klemenkova, N. A. Bondarenko, I. Odinets   +4 more
semanticscholar   +1 more source

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum's Acid and Aza-Michael Strategies. [PDF]

Molecules
Voznikaitė P, Račkauskienė G, Dagilienė M, Sløk FA, Šačkus A.   +4 more
europepmc   +1 more source

Synthetic Applications of Intramolecular Aza‐Wittig Reaction for the Preparation of Heterocyclic Compounds

, 2009
F. Palacios, Domitila Aparicio, G. Rubiales, C. Alonso, J. M. de los Santos   +4 more
semanticscholar   +1 more source

MultiCOIN: Multi‐Modal COntrollable INbetweening

Computer Graphics Forum, EarlyView.
Abstract Video inbetweening creates smooth transitions between two frames making it an indispensable tool for video editing and longform video synthesis. Existing methods struggle with large or complex motion and offer limited control over intermediate frames, often misaligning with user intent.
M. Tanveer, Y. Zhou, S. Niklaus, A. Mahdavi Amiri, H. Zhang, K. K. Singh, N. Zhao   +6 more
wiley   +1 more source

Synthesis and Characterization of Carbazole-Containing Aza[7]helicenes. [PDF]

Chemistry
Marten I, Dilanas MEA, Podlech J.
europepmc   +1 more source