Results 61 to 70 of about 5,363,495 (332)

Diminished effects of 5-aza-dC (Aza) in TET1-depleted HCT116 cells.

, 2016
(A) Analysis of DNA methylation (upper panel) and expression of representative tumor suppressor genes (lower panel) in control and TET1 knockdown HCT116 cells treated with or without Aza. Methylation levels at 2 CpG sites in DKK3, 3 CpG sites in SFRP1, 4
Masahiro Kai (775808), Tamotsu Sugai (144544), Eiichiro Yamamoto (52787), Reo Maruyama (52782), Hironori Aoki (3559973), Yasushi Sasaki (52790), Takeshi Niinuma (775807), Hiromu Suzuki (52785), Hiroshi Kitajima (3009357), Mutsumi Toyota (3559970), Hiroshi Nakase (783451), Taku Harada (3559967), Takashi Tokino (52798)   +12 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Reactivity Comparison of D–Glucose–Derived Dienophiles. Analysis of the Conformational and Electronic Properties

Molecules, 2000
Semiempirical calculations were performed to carry out a conformational analysis for carbohydrate-derived dienophiles 1-4. For α,β-unsaturated carbonylic compounds 2-4, a good correlation between Diels-Alder reactivity with calculated values for ...
S. C. Pellegrinet, M. T. Baumgartner, R. A. Spanevello   +2 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Synthesis of Triazole Derivatives of Levoglucosenone As Promising Anticancer Agents: Effective Exploration of the Chemical Space through retro-aza-Michael//aza-Michael Isomerizations

, 2018
The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents are described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by
Alejandra G. Suárez (1554907), Felipe Terra Martins (1755655), Yi-hsuan Tsai (4922848), Carla M. Borini Etichetti (4922851), Javier E. Girardini (4922845), Ariel M. Sarotti (1366479), Rolando A. Spanevello (1554910), Carolina Di Benedetto (3937550)   +7 more
core   +4 more sources

Novel Examples of 3-Aza-Grob Fragmentation

, 2016
Novel Examples of 3-Aza-Grob ...
Jeh-Jeng Wang (1633303), Pei-Ching Tsai (2716432), Wan-Ping Hu (1633315)   +2 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Chlorine-Substituted 9,10-Dihydro-9-aza-10-boraanthracene as a Precursor for Various Boron- and Nitrogen-Containing π‑Conjugated Compounds

, 2019
Chlorine-substituted 9,10-dihydro-9-aza-10-bora­anthracene was synthesized. Derivatization of this compound by taking advantage of the transformable B–Cl moiety gave 9,10-dihydro-9-aza-10-boraanthracene derivatives with various aryl substituents.
Shin-ya Nema (6426149), Makoto Yamashita (216887), Yutaro Ishikawa (6426146), Katsunori Suzuki (458282), Kohei Hayashi (2491297)   +4 more
core   +2 more sources

Chemical Composition of the Essential Oil of Psidium caudatum McVaugh

Molecules, 2002
The chemical composition of the essential oil of Psidium caudatum McVaugh was investigated and thirty-two compounds were identified by HRGC-MS. The main constituents were terpinen-4-ol (47.72%), γ-terpinene (11.58%) and α-terpinene (6.70%).
Luis Roberto Sánchez, Fredy Solano, Martha Lucía Pinzón, Xiomara Yáñez   +3 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source