Results 71 to 80 of about 5,363,495 (332)

Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives

open access: yesMolecules, 2008
The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.
Antonio Monge   +10 more
doaj   +1 more source

An Extremely Facile Aza-Bergman Rearrangement of Sterically Unencumbered Acyclic 3-Aza-3-ene-1,5-diynes

open access: yes, 2016
The factors that affect the kinetics of the aza-Bergman cyclization of aza-enediynes (C,N-dialkynyl imines) have not previously been elucidated. Here we report our kinetic studies of the aza-Bergman reactions of a series of 6-triisopropylsilyl and 6 ...
Dalip Kumar (467427)   +2 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro   +6 more
wiley   +1 more source

Utility of Sulphones in Heterocyclic Synthesis: Synthesis of Some Pyridine, Chromene and Thiophene Derivatives

open access: yesMolecules, 2000
Phenylsulfonylacetonitrile (1) when reacted with α,β-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the iminochromene derivative (4) respectively.
M. E. A. Zaki   +2 more
doaj   +1 more source

Ab Initio Investigation of the 3-Aza-Cope Reaction

open access: yes, 2016
The energies of reaction and activation for three archetypal aliphatic 3-aza-Cope reactions have been investigated by MP4/6-31G*//MP2/6-31G* calculations.
Michael A. Walters (486126)
core   +1 more source

Real‐world effectiveness and safety of secukinumab in giant cell arteritis: an Italian multicentre cohort study

open access: yesArthritis Care &Research, Accepted Article.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in giant cell arteritis (GCA) patients. Methods This multicentre retrospective study included patients with GCA who received secukinumab at 14 Italian centres with at least 6 months of follow‐up.
Luca Iorio   +29 more
wiley   +1 more source

Chemo- and Stereoselective Reduction of Polyfunctional Carbonyl Compounds by Mucor rouxii

open access: yesMolecules, 2000
Several polyfunctional carbonyl compounds, such as α- and β-ketoesters, were chemo- and stereoselectively reduced by Mucor rouxii cultures in water and in organic solvents.
Constanza P. Mangone   +3 more
doaj   +1 more source

High‐Efficiency Deep Blue Single‐Gaussian Europium(II) Emitters and Their Emitter‐Host Interactions

open access: yesAdvanced Functional Materials, EarlyView.
Crown‐ether ligands and carborate anions enable vacuum‐processable Eu(II) emitters with efficient single‐Gaussian deep‐blue luminescence. Combined photophysical and computational analyses reveal that excited‐electron confinement and steric shielding of the europium center jointly govern compatibility with OLED host materials, establishing molecular ...
Mahmoud Soleimani   +8 more
wiley   +1 more source

Immunomodulatory Effect of Aza-Spirocyclic Frameworks

open access: yesFrontiers in Bioscience-Landmark
Background: Immunomodulators play a central role in the treatment of cancer and immune-mediated disorders. Small-molecule immunomodulators are particularly attractive due to their structural diversity, pharmacological versatility, and ...
Anjali Prajapati   +3 more
doaj   +1 more source

Two New Flavonol Glycosides from Sarcopyramis bodinieri var. delicate

open access: yesMolecules, 2008
Detailed chemical investigation of the herb Sarcopyramis bodinieri var. delicate resulted in the isolation of two new flavonol glycosides, namely, isorhamnetin-3-O-(6′′-OE- feruloyl)-β-D-glucopyranoside (1) and isorhamnetin-3-O-(6′â ...
Yan Qiu   +3 more
doaj   +1 more source

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