Results 21 to 30 of about 463 (98)

The recent outbreaks of human coronaviruses: A medicinal chemistry perspective

Medicinal Research Reviews, Volume 41, Issue 1, Page 72-135, January 2021., 2021
Abstract Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal. Since the start of the 21st century, three β‐coronaviruses have crossed the species barrier to infect humans: severe‐acute respiratory syndrome (SARS)‐CoV‐1, Middle East
Thanigaimalai Pillaiyar, Lukas L. Wendt, Manoj Manickam, Maheswaran Easwaran   +3 more
wiley   +1 more source

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

Molecules, 2013
The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitrogen for the α-carbon of the aspartate residue in the sweetener S,S-aspartame.
Samir H. Bouayad-Gervais, William D. Lubell   +1 more
doaj   +1 more source

Struktuurimõjud asa-peptiidsideme moodustumise reaktsioonis [PDF]

, 2023
Väitekirja elektrooniline versioon ei sisalda publikatsiooneAsa-peptiidid on peptiidi analoogid, mis lagunevad elusorganismis aeglasemalt ja on seetõttu paljulubavad ravimikandidaadid.
Arujõe-Sado, Meeli
core  

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases.
Thomas S. Corrigan, Leilani M. Lotti Diaz, Sarah E. Border, Steven C. Ratigan, Kayla Q. Kasper, Daniel Sojka, Pavla Fajtova, Conor R. Caffrey, Guy S. Salvesen, Craig A. McElroy, Christopher M. Hadad, Özlem Doğan Ekici   +11 more
doaj   +1 more source

Submonomer Synthesis and Structure-activity Relationship Studies of Azapeptide Inhibitors of the Insulin Receptor Tyrosine Kinase [PDF]

, 2014
Azapeptides are a class of peptide mimics (peptidomimetics), which have served as valuable tools for the development of peptide based therapeutic agents.
Kurian, Lathamol A.
core   +3 more sources

The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development [PDF]

, 2017
Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design.
Danelius, Emma
core   +1 more source

Dyslipidaemia associated with the highly active antiretroviral therapy in aids patient: reversion after switching (stavudine to tenofovir and lopinavir/ritonavir to atazanavir/ritonavir) [PDF]

, 2007
Antiretroviral therapy has been associated with hyperlipidemia in AIDS patients. This case illustrates the classic metabolic effects associated to the HAART including protease inhibitors and/or stavudine.
Cunha, Rivaldo Venâncio da, Domingos, Hamilton, Paniago, Anamaria Mello Miranda   +2 more
core   +2 more sources

Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis

AIDS Research and Treatment, Volume 2015, Issue 1, 2015., 2015
The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients.
C. I. Marinescu, M. Leyes, M. A. Ribas, M. Peñaranda, J. Murillas, A. A. Campins, L. Martin-Pena, B. Barcelo, C. Barceló-Campomar, F. Grases, G. Frontera, Melchor Riera Jaume, Glenda Gray   +12 more
wiley   +1 more source

Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC‐MS/MS

The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014
Objectives. HIV protease inhibitors are used in the treatment of patients suffering from AIDS and they act at the final stage of viral replication by interfering with the HIV protease enzyme. The paper describes a selective, sensitive, and robust method for simultaneous determination of three protease inhibitors atazanavir, darunavir and ritonavir in ...
Tulsidas Mishra, Pranav S. Shrivastav, T. Kaneta, S. Lee, Y. Lu   +4 more
wiley   +1 more source

The Continuing Evolution of HIV‐1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets

Molecular Biology International, Volume 2012, Issue 1, 2012., 2012
During the past three decades, over thirty‐five anti‐HIV‐1 therapies have been developed for use in humans and the progression from monotherapeutic treatment regimens to today’s highly active combination antiretroviral therapies has had a dramatic impact on disease progression in HIV‐1‐infected individuals. In spite of the success of AIDS therapies and
Tracy L. Hartman, Robert W. Buckheit Jr., Gilda Tachedjian   +2 more
wiley   +1 more source