Computational studies of mutations associated to resistance in HIV-1 macromolecular targets and implications in rational design of novel antiviral agents [PDF]
, 2008 Al fine di identificare nuovi farmaci anti-HIV capaci di superare i problemi legati alla resistenza, è stato condotto uno studio teorico combinando l’analisi strutturale sui modelli cristallografici della trascrittasi inversa (RT), i dati clinici ...
ARTESE, ANNA
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STABILITY-INDICATING VALIDATED REVERSED PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS DETERMINATION OF COBICISTAT AND ATAZANAVIR SULFATE IN BULK AND PHARMACEUTICAL DOSAGE FORM [PDF]
, 2016 Objective: A simple, rapid, precise, accurate, and economical stability-indicating reversed phase-high performance liquid assay method was developedand validated for simultaneous estimation of cobicistat (COB) and atazanavir (ATV) sulfate in bulk drugs ...
Kumar T, Anil +5 more
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Azapeptide Carbonyls: A New Class of 20S Proteasome Inhibitors [PDF]
, 2019 STEP Category: Undergraduate ResearchThe proteasome is a critical component of the ubiquitin-proteasome pathway (UPP) that is responsible for quality control of newly synthesized proteins in eukaryotic cells.
Kucway, Kayla
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Ühe-poti sünteesimeetod kaitstud bensüülhüdrasiinide saamiseks [PDF]
, 2016 Antud töö tulemusena loodi mugav ja kiire meetod kaitstud bensüül- ning asendatud bensüülhüdrasiinide saamiseks, mis võimaldas kasutada lähteainetena nii bensaldehüüdi atsetaali kui ka diatsetaati ning vältida karbonüülühendi kaitserühma mahavõtmist ...
Niinepuu, Siret
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Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers. [PDF]
Proc Natl Acad Sci U S A, 2022 Habashi M +14 more
europepmc +1 more source
Les azasulfurylpeptides : synthèse, analyse conformationnelle et applications biologiques [PDF]
, 2015 Les azasulfurylpeptides sont des mimes peptidiques auxquels le carbone en position alpha et le carbonyle d’un acide aminé sont respectivement remplacés par un atome d’azote et un groupement sulfonyle (SO2). Le but premier de ce projet a été de développer
Turcotte, Stéphane
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Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates. [PDF]
Nat Commun, 2022 Altiti A +19 more
europepmc +1 more source
, 2012 Les accouchements prématurés constituent un problème médical majeur en constante augmentation et ce, malgré tous les efforts mis en œuvre afin de contrer le déclenchement des contractions avant terme.
Bourguet, Carine B.
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L'ischémie myocardique est une condition causée par l'obstruction des artères responsables de la circulation sanguine vers le myocarde, limitant ainsi l'apport en oxygène et en nutriments.
Radmannia, Naghme
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Design, Synthesis And Analysis Of Potential Photo-Activatable Cathepsin K Inhibitors [PDF]
, 2017 DESIGN, SYNTHESIS AND ANALYSIS OF POTENTIAL PHOTO-ACTIVATABLE CATHEPSIN K INHIBITORS by KHALIN NISBETT May 2017 Advisor: Dr. Jeremy Kodanko Major: Chemistry Degree: Master of Science Tightly regulated cysteine CA proteases play a major role in ...
Nisbett, Khalin Evania
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