Results 141 to 150 of about 1,295 (195)

Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis

Bioorganic and Medicinal Chemistry, 2009
Martin Giera, Franz Bracher
exaly   +2 more sources

Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

Steroids, 2015
Suresh Thareja
exaly   +2 more sources

13C-NMR study of 4-azasteroids in solution and solid state

Steroids, 2002
Jacek W Morzycki, Iwona Wawer, Jadwiga MAJ   +2 more
exaly   +2 more sources

Recent advances in azasteroids chemistry.

Steroids, 2008
Modified steroids have attracted a great deal of attention these last years. Their preparation is a stimulating challenge to the organic chemist, often demanding development of new and generally useful reactions. Moreover, the biological properties of modified steroids have proved to be of interest.
Malika Ibrahim-ouali, L. Rocheblave
semanticscholar   +3 more sources

A microwave promoted and Lewis acid catalysed solventless approach to 4-azasteroids

Steroids, 2008
Romesh C Boruah
exaly   +2 more sources

N-Alkylation of 17-azasteroids

Steroids, 1994
N-Alkylation of 17-azasteroid lactams (16-oxo-17-azaandrost-5-en-3 beta-ol acetate 3 and its D-homo analog 4) was studied. It has been found that both lactams are readily alkylated with iodomethane or iodoethane. In contrast to this there was no reaction with 2-iodo-6-methylheptane due to the steric hindrance.
Jacek W Morzycki
exaly   +3 more sources

Phosphorescence of 8-azasteroids and related compounds

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2005
We have investigated the electron absorption, fluorescence and phosphorescence spectra of 8-azasteroids and model compounds containing enaminodicarbonyl fragment. It has been shown that the investigated compounds have absorption and phosphorescence spectra similar in form and position.
S A Bagnich
exaly   +3 more sources

Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity.

Steroids, 2020
In this work, we report the synthesis of two new azasteroids through the modification of the A and B rings of diosgenin 1. The 4-azasteroid derivative 12 was prepared in three steps using the α,β-insaturated-3-keto compound 11 as a precursor, which was ...
Anselmo A. Martínez-Gallegos, Gabriel Guerrero-Luna, Alejandra Ortiz-González, M. Cárdenas-García, S. Bernès, María Guadalupe Hernández-Linares   +5 more
semanticscholar   +1 more source

19-nor-10-azasteroids, a new class of steroid 5 alpha-reductase inhibitors. 2. X-ray structure, molecular modeling, conformational analysis of 19-nor-10-azasteroids and comparison with 4-azasteroids and 6-azasteroids.

Journal of Medicinal Chemistry, 1997
A. Guarna, E. Occhiato, F. Machetti, A. Marrucci, G. Danza, M. Serio, P. Paoli   +6 more
semanticscholar   +2 more sources

ChemInform Abstract: AZASTEROIDE 1. MITT. SYNTH. EINES AZASTEROID‐RINGSYST.

Chemischer Informationsdienst. Organische Chemie, 1970
AbstractBeim Erhitzen von 2‐(1‐Cyclohexenyl)‐ähhylamin (I) mit dem Ester (II) am Rückfluß entsteht das Enaminlactam (III) (als Doppelbindungsisomerengemisch) in einer Ausbeute von 86%.
S. OHKI, M. AKIBA
openaire   +1 more source