Results 211 to 220 of about 97,080 (283)

Cholesterol and Cholesterol‐Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels

open access: yesArchiv der Pharmazie, Volume 359, Issue 6, June 2026.
Cholesterol, steroid hormones, and cholesterol‐based imidazolium salts (CHIMs) inhibit Kv7.2/Kv7.3 channels. Notably, NBD‐tagged CHIM‐L enhances currents. These findings demonstrate that both chemical modifications and linker length differentially modulate Kv7 activity, revealing variant‐specific sensitivities and potential pharmacological targets for ...
Elif Karabatak   +6 more
wiley   +1 more source

Fungicidal Activity and In Silico Studies of Triazoles Derived From Glycerol Against Neocosmospora falciformis, A Causal Agent of Guava Tree Decline

open access: yesChemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Among seventeen 1,2,3‐triazoles synthetized from glycerol (4a–4q), compound 4l completely inhibited mycelial growth and eliminated N. falciformis spores at 1,000 µg/mL, exhibiting enhanced antifungalactivity and strong binding within the FsCYP51 active site, which highlights its promise as a lead candidate for antifungal development in both biological ...
Adilson Vidal Costa   +12 more
wiley   +1 more source

Soft Ferroelectrics in One Dimension: Ferroelectric Columnar Liquid Crystals

open access: yesChemPlusChem, Volume 91, Issue 6, June 2026.
Helical ferroelectric columnar liquid crystals (FCLCs) confine bistable axial polarization within individual columns. An electric field reversibly flips the macrodipole, enabling two nonvolatile states readable as “0” and “1.” This Cconcept highlights supramolecular locking and helical architectures that deliver genuine switching and long‐lived zero ...
Seongwon Park, Byoung‐Ki Cho
wiley   +1 more source

Light‐Activated Nucleic Acid Amplification Systems Using Photo‐Caged DNA Polymerase or Primers

open access: yesAdvanced Genetics, Volume 7, Issue 2, June 2026.
ABSTRACT Precise control over nucleic acid amplification is essential for achieving reliable, quantitative, high‐throughput, and multiplexed molecular diagnostics, particularly in point‐of‐care and field settings. However, conventional isothermal amplification methods, especially rapid assays at ambient temperature such as recombinase‐aided ...
Yang Wu   +20 more
wiley   +1 more source

Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang   +8 more
wiley   +1 more source

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen   +11 more
wiley   +1 more source

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