Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Contributions of Sound Localization Cues to Azimuth Tuning in the Auditory Midbrain. [PDF]
Garretson E, Mencsik J, Day ML.
europepmc +1 more source
Influence Mechanism of Quantization Error on the Key Parameters of the Whole-Angle Hemisphere Resonator Gyroscope. [PDF]
Yan X +7 more
europepmc +1 more source
Multifunctional Metasurfaces for Bridging Terahertz Waves in Free Space and Waveguides
A multifunctional terahertz metasurface capable of simultaneous orthogonal polarization conversion and phase modulation is integrated onto a dielectric slab waveguide, thereby enabling efficient free‐space‐to‐guided‐wave coupling. By implementing tailored phase gradients on the metasurface, we demonstrate the formation of a focused spot within the ...
Jinhui Lu +5 more
wiley +1 more source
Dynamic Beam Control-Based Neighbor Discovery Protocol for Underwater Acoustic Networks with Multi-Parallel Transceiver. [PDF]
Zhang J, Zhou L, Wang H, Zeng Z, Hu Q.
europepmc +1 more source
An elastic segment was found in the basal part of the whisker shaft in rats and mice. Application of force to the whisker bulb of isolated follicles caused bending and twisting of this segment. Active whisker movements deform this segment, causing whisker shaft deflection and selective activation of mechanoreceptors at different phases of whisking ...
Sebastian Haidarliu +4 more
wiley +1 more source
High-Accuracy Wave Direction Estimation Using Kalman Fusion of Interferometric Measurements and Energy Field Reconstruction. [PDF]
Wang C, Li X, Xue L.
europepmc +1 more source
Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo +5 more
wiley +1 more source
Correction: Achievable directive antenna gain measurements and modeling for 60 GHz indoor links. [PDF]
Bruna S +8 more
europepmc +1 more source
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban +13 more
wiley +1 more source

