Accessing Arene-Fused Eight-Membered Carbo- and Heterocycles via Bidentate Lewis Acid Catalysis [PDF]
Eight-membered carbo- and heterocycles constitute unique structural elements not only found in a plethora of biologically active natural products and medicinally relevant synthetic compounds, but also in various functional molecules and materials ...
Große, Michel
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Suppressing Inversion of a Chiral Polycyclic Aromatic Aza Monkey Saddle by Molecular Editing
Helvetica Chimica Acta, Volume 107, Issue 12, December 2024.Abstract Chiral polycyclic aromatic hydrocarbons with monkey saddle topology are a fascinating class of negatively curved compounds. To make the monkey‐saddles valuable building blocks for chirality‐assisted synthesis (CAS) approaches, the inversion barriers between the two possible enantiomers need to be high enough to prevent interconversion under ...
Tobias Kirschbaum +3 more
wiley +1 more source
Conjugating Hemoglobin and Albumin by Strain‐Promoted Azide‐ Alkyne Cycloaddition
ChemBioChem, Volume 25, Issue 16, August 19, 2024.Strain‐promoted azide‐alkyne cycloaddition (SPAAC) of site‐selectively cross‐linked human hemoglobin with specifically modified human serum albumin yields a structurally defined protein‐protein conjugate. A circulating solution of the conjugate can provide cooperative oxygen transport and maintain colloid osmotic pressure.
Chi Lee +2 more
wiley +1 more source
Recent advances on the catalytic asymmetric allylic α-alkylation of carbonyl derivatives using free allylic alcohols [PDF]
During the last years, the development of more sustainable and straightforward methodologies to minimize the generation of waste organic substances has acquired high importance within synthetic organic chemistry. Therefore, it is not surprising that many
Alonso, Diego A +3 more
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Molecular structure and conformations of eight-membered cyclic acetals with 1,4-diplanar fragments [PDF]
, 1995 The molecular structures of nine eight-membered cyclic acetals containing two planar fragments in the ring, the derivatives of dibenzo- and dinaphtho[d,g][1,3]dioxocines, have been studied by x-ray single crystal diffraction.
Anonimova I. +3 more
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Approaches to the synthesis of azabullvalene [PDF]
, 1973 Three approaches to the synthesis of the heretofore unknown azabullvalene, the pi electron equivalent heterocyclic congener of bullvalene itself, are described.
Steinheimer, Thomas Rudolph
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Advances in synthesis of novel annulated azecines and their unique pharmacological properties [PDF]
Annulated azecines, mostly partially saturated benzo[d]azecine and dibenzo[c,g]azecine fusion isomers, constitute a unique class of alkaloids and nature-inspired azaheterocyclic compounds with interesting reactivity, physicochemical and biological ...
Altomare, Cosimo D. +8 more
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A novel bridgehead azocine. The end of a controversy.
Tetrahedron, 1992 A novel bridgehead azocine has been obtained from aminopyran 1 and benzylidinemalononitrile . The structure of was confirmed by X-ray diffraction. A novel bridgehead azocine has been obtained and the structure confirmed by X-ray diffraction. The authors wish to thank the Commision Interministerial de Ciencia y Tecnologia of Spain for financial ...
Martín, Nazario +5 more
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Preparation and Reactions of 1, 5-bis (p-substituted Phenyl) Octahydro-3, 7-Disubstituted-1, 5-Diazocines [PDF]
, 1976 The purpose of this research was to synthesize and study the reactions of 1,5-bis-(p-substituted phenyl)octahydro-3, 7-disubstituted-1, 5-diazocines.
Odle, Roy R.
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Microwave-Promoted Synthesis of Bicyclic Azocine-β-Lactams from Bis(allenes)
The Journal of Organic Chemistry, 2014 A metal-free preparation of structurally novel bicyclic azocine-β-lactams has been developed. The first examples accounting for the preparation of eight-membered rings from bis(allenes) in the absence of metals have been achieved by the thermolysis of nonconjugated 2-azetidinone-tethered bis(allenes) on application of microwave irradiation.
Alcaide, Benito +4 more
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