Results 281 to 290 of about 56,531 (323)
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Expert Opinion on Emerging Drugs, 2005
Systemic and superficial fungal infections have progressively emerged over the past few decades as an increasing cause of human disease, especially in the immunocompromised host. Control of fungal disease has proved difficult because few risk factors are potentially preventable; the population at highest risk for fungal disease, the immunocompromised ...
Anne Chen, Jack D. Sobel
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Systemic and superficial fungal infections have progressively emerged over the past few decades as an increasing cause of human disease, especially in the immunocompromised host. Control of fungal disease has proved difficult because few risk factors are potentially preventable; the population at highest risk for fungal disease, the immunocompromised ...
Anne Chen, Jack D. Sobel
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Acta Crystallographica Section C Crystal Structure Communications, 2000
The structure analyses of racemic 3-chloro-1-(4-morpholino-5-nitroimidazol-1-yl)propan-2-ol, C(10)H(15)ClN(4)O(4), (II), and 3-chloro-1-(5-morpholino-4-nitroimidazol-1-yl)propan-2-ol, C(10)H(15)ClN(4)O(4), (III), have been undertaken in order to determine the position of the morpholine residue in these two isomers.
Andrzej Gzella +2 more
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The structure analyses of racemic 3-chloro-1-(4-morpholino-5-nitroimidazol-1-yl)propan-2-ol, C(10)H(15)ClN(4)O(4), (II), and 3-chloro-1-(5-morpholino-4-nitroimidazol-1-yl)propan-2-ol, C(10)H(15)ClN(4)O(4), (III), have been undertaken in order to determine the position of the morpholine residue in these two isomers.
Andrzej Gzella +2 more
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Reaction of tetracyanoquinodimethane with azoles [PDF]
Chemistry of Heterocyclic Compounds, 1976 The reaction of tetracyanoquinodimethane (TCQD) with azoles was studied. It was found that products of 1,6 addition to the quinoid system of TCQD are formed with pyrrole, indole, and their methyl derivatives. The addition products split out HCN under the influence of UV light to give deeply colored products of replacement of one nitrile group in TCQD ...
E. V. Getmanova +3 more
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Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles
The Journal of Organic Chemistry, 2014AbstractA slight excess (1.2 equiv.) of difluoroalkene reacts with various N‐heterocycles to afford monosubstituted (E)‐configurated products.
Xuxue Zhang +3 more
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Trifluoromethanesulfonamide derivatives of azoles
Journal of Fluorine Chemistry, 2011Abstract Trifluoromethanesulfonamide-substituted azoles were synthesized by the reaction of 5-aminotetrazole, 3-amino-1,2,4-triazole and 3,5-diamine-1,2,4-triazole with trifluoromethanesulfonyl fluoride to prepare only monosubstituted compounds. All the compounds were fully characterized using ( 1 H, 19 F, 13 C) NMR spectroscopy, mass spectrometry (
Jean'ne M. Shreeve, Sonali Garg
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Clinical Infectious Diseases, 1992
The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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N-(Difluoroamino)azoles – a new class of N-substituted azoles
Mendeleev Communications, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
V. M. Vinogradov +3 more
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, 2016 Azole antifungal agents, primarily the triazoles fluconazole, itraconazole, voriconazole and posaconazole, are in widespread clinical use for the management of systemic fungal infections. Their application in the prophylaxis against and treatment of systemic mycoses continues to evolve, with ongoing advancements in drug delivery, efficacy, monitoring ...
Nicolette R. Holt, Karin A Thursky
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Médecine et Maladies Infectieuses, 1984
Resume Les premiers azoles antifongiques possedent un spectre d'activite restreint. L'etonam (R 10100) etait actif contre les dermatophytes a la fois in vitro et in vivo par application topique. Le spectre antimycosique dans le traitement topique s'est elargi avec le miconazole et le clotrimazole.
P. A. J. Janssen, J. Van Cutsem
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Resume Les premiers azoles antifongiques possedent un spectre d'activite restreint. L'etonam (R 10100) etait actif contre les dermatophytes a la fois in vitro et in vivo par application topique. Le spectre antimycosique dans le traitement topique s'est elargi avec le miconazole et le clotrimazole.
P. A. J. Janssen, J. Van Cutsem
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