Results 1 to 10 of about 30,688 (283)
International Journal of Molecular Sciences, 2021 Azoospermia affects 1% of men, and it can be due to: (i) hypothalamic-pituitary dysfunction, (ii) primary quantitative spermatogenic disturbances, (iii) urogenital duct obstruction. Known genetic factors contribute to all these categories, and genetic testing is part of the routine diagnostic workup of azoospermic men.
Francesca Cioppi, Csilla Krausz
exaly +5 more sources
Nature Communications, 2020 Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the ...
Liangyu Zhao, Chencheng Yao, Chao Yang
exaly +3 more sources
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing
Signal Transduction and Targeted Therapy, 2022 Dear Editor, Male infertility is a multifactorial heterogeneous pathological condition affecting ∼7% of men. Nonobstructive azoospermia (NOA) is one of the most severe male reproductive diseases and occurs in ∼1% of men of reproductive age.
Chencheng Yao, Zhiyong Ji, Yaoting Gui
exaly +2 more sources
Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia
Regulatory Mechanisms in Biosystems, 2021 Over the past 20 years, there has been a clear trend to increase in the number of infertile men in Ukraine, their percentage reaches 50% in infertile couples. There is a significant percentage of male infertility caused by azoospermia – the lack of sperm
M. Z. Vorobets +5 more
doaj +3 more sources
The gene regulatory role of non-coding RNAs in non-obstructive azoospermia
Frontiers in Endocrinology, 2022 Non-coding RNAs are classified as small non-coding RNAs, long non-coding RNAs and circular RNAs, which are involved in a variety of biological processes, including cell differentiation, proliferation, apoptosis and pathological conditions of various ...
Guanqing Zhou +15 more
doaj +2 more sources
Reproductive Biology and Endocrinology, 2022 Background There is a lack of biomarkers for distinguishing non-obstructive azoospermia (NOA) patients with successful sperm retrieval (Sp+) from those with failed sperm retrieval (Sp-).
Xiaoxiao Han +10 more
doaj +2 more sources
Human Reproduction Update, 2019 BACKGROUND Factor affecting sperm retrieval rate (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in patients with non-obstructive azoospermia (NOA) have not been systematically evaluated.
Giovanni Corona +2 more
exaly +2 more sources
Genetic Factors of Non-Obstructive Azoospermia: Consequences on Patients’ and Offspring Health [PDF]
Journal of Clinical Medicine, 2021 Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and is characterized by clinical heterogeneity implying the involvement of several different acquired and genetic factors.
C. Krausz, F. Cioppi
semanticscholar +2 more sources
Cell-Based Therapy Approaches in Treatment of Non-obstructive Azoospermia [PDF]
Reproductive Sciences, 2022 The rate of infertility has globally increased in recent years for a variety of reasons. One of the main causes of infertility in men is azoospermia that is defined by the absence of sperm in the ejaculate and classified into two categories: obstructive ...
E. Roshandel +6 more
semanticscholar +2 more sources
Predictors of testicular sperm retrieval in patients with non-obstructive azoospermia: a review
Journal of International Medical Research, 2021 Azoospermia is divided into two categories of obstructive azoospermia and non-obstructive azoospermia. Before 1995, couples with a male partner diagnosed with non-obstructive azoospermia had to choose sperm donation or adoption to have a child. Currently,
Lin Qi, Ya P Liu, Nan N Zhang, Ying C Su
doaj +2 more sources