Sperm recovery and IVF after testicular sperm extraction (TESE): effect of male diagnosis and use of off-site surgical centers on sperm recovery and IVF. [PDF]
PLoS ONE, 2013 Determine whether testicular sperm extractions and pregnancy outcomes are influenced by male and female infertility diagnoses, location of surgical center and time to cryopreservation.One hundred and thirty men undergoing testicular sperm extraction and ...
Kenan Omurtag +6 more
doaj +1 more source
Journal of International Medical Research, 2020 Objective The objective was to investigate the frequency and type of chromosomal abnormalities and Y chromosome microdeletions in infertile men with azoospermia and oligozoospermia to ensure appropriate genetic counseling before assisted reproduction in ...
Jing Sha +5 more
doaj +1 more source
Copy number variations (CNVs) and karyotyping analysis in males with azoospermia and oligospermia
BMC Medical Genomics, 2023 Background Considering the essential roles that genetic factors play in azoospermia and oligospermia, this study aims to identify abnormal chromosomes using karyotyping and CNVs and elucidate the associated genes in patients.
Xing Xin +11 more
doaj +1 more source
Andrology laboratory technique for analysis of semen in men with azoospermia
Asian Journal of AndrologyDiscovery of spermatozoa during the 17th century led to developing technologies for semen analysis in the early 1900s, and then, standard techniques were implemented during the 20th century.
Andrian Japari +2 more
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Management of the Infertile Male with Azoospermia
Düzce Tıp Fakültesi Dergisi, 2022 Azoospermia means the complete absence of spermatozoa upon examination of the semen. Azoospermia may result from a lack of spermatozoa production in the testicles, or from an inability of produced spermatozoa to reach the emitted semen.
Erdem Akbay, Mesut Tek
doaj +1 more source
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, EarlyView.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, EarlyView.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
Differentiation between nonobstructive azoospermia and obstructive azoospermia: then and now
Asian Journal of AndrologyMale infertility has seen an increase in prevalence with cases of azoospermia estimated to affect 10%–15% of infertile men. Confirmation of azoospermia subsequently necessitates an early causal differentiation between obstructive azoospermia (OA) and ...
Logan Hubbard +2 more
doaj +1 more source
A Novel Mutation of DAX-1 Associated with Secretory Azoospermia. [PDF]
PLoS ONE, 2015 Secretory azoospermia is a severe form of male infertility caused by unknown factors. DAX-1 is predominantly expressed in mammalian reproductive tissues and plays an important role in spermatogenesis because Dax-1 knockout male mice show spermatogenesis ...
Lisha Mou +7 more
doaj +1 more source
Chronic Immune-Mediated Orchitis Is the Major Cause of Acquired Non-obstructive Azoospermia in Dogs
Frontiers in Veterinary Science, 2022 Azoospermia, the lack of spermatozoa in the ejaculate, is the most common finding in infertile but otherwise healthy male dogs and represents an increasing reproductive health issue in men, too.
Sandra Goericke-Pesch +7 more
doaj +1 more source