Results 41 to 50 of about 660 (230)
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Eight-Bar Elbow Joint Exoskeleton Mechanism
This paper deals with the design and kinematic analysis of a novel mechanism for the elbow joint of an upper-limb exoskeleton, with the aim of helping operators, in terms of effort and physical resistance, in carrying out heavy operations. In particular,
Giorgio Figliolini +3 more
doaj +1 more source
Interpretations of the new LHCb $$P_c(4337)^+$$ P c ( 4337 ) + pentaquark state
Recently the LHCb Collaboration has observed a new pentaquark state, the $$P_c(4337)^+$$ P c ( 4337 ) + . Owing to its proximity to the $$\chi _{c0}(1S) p$$ χ c 0 ( 1 S ) p , $${\bar{D}}^* \varLambda _c$$ D ¯ ∗ Λ c , $${\bar{D}} \varSigma _c$$ D ¯ Σ c ...
Mao-Jun Yan +3 more
doaj +1 more source
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Fıkhın ana kaynakları Kur'ân-ı Kerîm ve Sünnettir. Arapça olan bu iki kaynağın metinlerini yorumlama üzerine İslam düşüncesinde ilk devirlerden itibaren yazılar yazılmıştır.
Kuru, Uğur, Telkenaroğlu, Merter Rahmi
core
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Let T be a set-valued contraction mapping on a general Banach space $\mathcal{B}$. In the first part of this paper we introduce the evolution inclusion $\dot x + x \in Tx$ and study the convergence of solutions to this inclusion toward fixed points of
Herb Kunze +3 more
doaj

