Results 41 to 50 of about 660 (230)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Eight-Bar Elbow Joint Exoskeleton Mechanism

open access: yesRobotics
This paper deals with the design and kinematic analysis of a novel mechanism for the elbow joint of an upper-limb exoskeleton, with the aim of helping operators, in terms of effort and physical resistance, in carrying out heavy operations. In particular,
Giorgio Figliolini   +3 more
doaj   +1 more source

Interpretations of the new LHCb $$P_c(4337)^+$$ P c ( 4337 ) + pentaquark state

open access: yesEuropean Physical Journal C: Particles and Fields, 2022
Recently the LHCb Collaboration has observed a new pentaquark state, the $$P_c(4337)^+$$ P c ( 4337 ) + . Owing to its proximity to the $$\chi _{c0}(1S) p$$ χ c 0 ( 1 S ) p , $${\bar{D}}^* \varLambda _c$$ D ¯ ∗ Λ c , $${\bar{D}} \varSigma _c$$ D ¯ Σ c ...
Mao-Jun Yan   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Exception in fiqh method

open access: yes, 2020
Fıkhın ana kaynakları Kur'ân-ı Kerîm ve Sünnettir. Arapça olan bu iki kaynağın metinlerini yorumlama üzerine İslam düşüncesinde ilk devirlerden itibaren yazılar yazılmıştır.
Kuru, Uğur, Telkenaroğlu, Merter Rahmi
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Continuous evolution of equations and inclusions involving set-valued contraction mappings with applications to generalized fractal transforms

open access: yesElectronic Journal of Differential Equations, 2014
Let T be a set-valued contraction mapping on a general Banach space $\mathcal{B}$. In the first part of this paper we introduce the evolution inclusion $\dot x + x \in Tx$ and study the convergence of solutions to this inclusion toward fixed points of
Herb Kunze   +3 more
doaj  

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