Results 31 to 40 of about 13,786,958 (257)

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia [PDF]

, 2022
Patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have a favorable prognosis. However, current treatment protocols are based on intensive cytotoxic chemotherapy and therapy options are limited when patients relapse. Hence, there is an
Gina Münch, Andrew G. Polson, Monika Brüggemann, Martin Schrappe, Denis M. Schewe, Cario, Gunnar, Vogiatzi, Fotini, Ulf D. Kahlert, Jumaa, Hassan, Christian Vokuhl, Mayar, Ahmad, Fotini Vogiatzi, Anna Dietterle, Vokuhl, Christian, Lennart Lenk, Schewe, Denis M., Schüler, Thomas, Münch, Gina, Schewe, Denis M, Winterberg, Dorothee, Spory, Lea, Lea Spory, Thomas Valerius, Polson, Andrew G., Richter, Julia, Ameera Alsadeq, Matthias Peipp, Dietterle, Anna, Kahlert, Ulf D., Brüggemann, Monika, Alsadeq, Ameera, Anna Laqua, Gunnar Cario, Valerius, Thomas, Schrappe, Martin, Ahmad Mayar, Hobeika, Elias, Elias Hobeika, Lenk, Lennart, Peipp, Matthias, Julia Richter, Dorothee Winterberg, Hassan Jumaa, Laqua, Anna, Thomas Schüler, Kahlert, Ulf D, Polson, Andrew G   +46 more
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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Haematologica, 2014
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment.
A. Margarida Gomes, Maria V. D. Soares, Patrícia Ribeiro, Joana Caldas, Vanda Póvoa, Leila R. Martins, Alice Melão, Ana Serra-Caetano, Aida B. de Sousa, João F. Lacerda, João T. Barata   +10 more
doaj   +1 more source

Immunophenotypic challenges in diagnosis of CD79a negativity in a patient with B acute lymphoblastic leukemia harboring intrachromosomal amplification of chromosome 21: a case report

Journal of Medical Case Reports, 2021
Background Being expressed in all stages of B-cell development and having a significant value on the European Group for the Immunological Characterization of Acute Leukemias scoring system, CD79a is considered as an excellent pan-marker for lineage ...
A. Berhili, M. Bensalah, J. ElMalki, A. Elyagoubi, R. Seddik   +4 more
doaj   +1 more source

A case report of secondary B-cell acute lymphoblastic leukemia treated with a combination of FLT3 inhibitor and decitabine

Frontiers in Oncology
Secondary acute lymphoblastic leukemia (s-ALL) refers to acute lymphoblastic leukemia that occurs after a previous malignant tumor, including therapy-related acute lymphoblastic leukemia (t-ALL) and prior malignant tumor acute lymphoblastic leukemia (pm ...
Mengci Hu, Wenzhe Li, Pan Li, Jie Tan, Ya Wang, Ya Wang   +5 more
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Intrachromosomal amplification of chromosome 21 (iAMP21) detected by ETV6/RUNX1 FISH screening in childhood acute lymphoblastic leukemia: a case report

Revista Brasileira de Hematologia e Hemoterapia, 2013
Chromosome abnormalities that usually define high-risk acute lymphoblastic leukemia are the t(9;22)/ breakpoint cluster region protein-Abelson murine leukemia viral oncogene homolog 1, hypodiploid with < 44 chromosomes and 11q23/ myeloid/lymphoid ...
Daniela Ribeiro Ney Garcia, Alejandro Mauricio Arancibia, Raul C. Ribeiro, Marcelo Gerardin Poirot Land, Maria Luiza Macedo Silva   +4 more
doaj   +1 more source

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]

, 2011
Background: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
Mahajna, Jamal, Y. Najajreh, Ruthardt, Martin, M. Ruthardt, Ottmann, Oliver G., J. Mahajna, Mian, Afsar Ali, Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, A. Metodieva, A. A. Mian, O. G. Ottmann   +12 more
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Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

Haematologica, 2011
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases.
Vera Grossmann, Wolfgang Kern, Stefan Harbich, Tamara Alpermann, Sabine Jeromin, Susanne Schnittger, Claudia Haferlach, Torsten Haferlach, Alexander Kohlmann   +8 more
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WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA [PDF]

Zagazig University Medical Journal, 2014
Aim &Objectives: Wilms ٰ ٰ tumor 1 (Wt1) gene is over expressed in majorty of acute leukemia.The aim of this study is to evaluate(WT1) gene expression in children with acute lymphoblastic leukemia and to find out the relationship between it and other
Mohamed Badr, Tamer Hassan, Asmaa Esh, Wesam Mokhtar   +3 more
doaj   +1 more source

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T., J. Mittermueller, D. Wiesner, S. Braun, H.M. Schmetzer, T. Duell, H.H. Gerhartz   +11 more
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Acute lymphoblastic leukemia and gingival enlargement – a case report

, 2021
Gingival enlargement is caused by various factors such as inflammation, medications and malignant diseases. Acute leukemic enlargement is commonly seen in children.
Neetha J. Shetty, Sameep Shetty, Raj, Akanksha, Akanksha Raj, Gayathri, S., Shetty, Neetha J., S. Gayathri, Shetty, Sameep   +7 more
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