Results 51 to 60 of about 13,786,958 (257)

Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report

Journal of Medical Case Reports, 2017
Background The translocation t(1;19)(q23;p13), which results in the TCF3-PBX1 chimeric gene, is one of the most frequent rearrangements observed in B cell acute lymphoblastic leukemia.
Abdulsamad Wafa, Manar As’sad, Thomas Liehr, Abdulmunim Aljapawe, Walid Al Achkar   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Acute Hepatitis A Induction of Precursor B-Cell Acute Lymphoblastic Leukemia:A Causal Relationship

Case Reports in Oncology, 2010
Background: Precursor B-cell acute lymphoblastic leukemia accounts for 2% of all lymphoid neoplasms in the United States and occurs most frequently in childhood, but can also occur in adults with a median age of 39 years.
V. Senadhi, D. Emuron, R. Gupta
doaj   +1 more source

COVID-19 infection during blinatumomab therapy: Is safety a dilemma?

SAGE Open Medical Case Reports, 2023
Patients with acute lymphoblastic leukemia may be particularly vulnerable to SARS-CoV-2 infection and severe illness. The mainstay of current treatment is the use of blinatumomab in patients with refractory or relapsed B-cell precursor acute ...
Julián E Barahona-Correa, Camilo Rueda-Ortiz, María-José López, Sandra Gualtero, Mónica Arevalo-Zambrano   +4 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome

Haematologica, 2011
Background LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center ...
Raquel Malumbres, Vicente Fresquet, Jose Roman-Gomez, Miriam Bobadilla, Eloy F. Robles, Giovanna G. Altobelli, M.ª José Calasanz, Erlend B. Smeland, Maria Angela Aznar, Xabier Agirre, Vanesa Martin-Palanco, Felipe Prosper, Izidore S. Lossos, Jose A. Martinez-Climent   +13 more
doaj   +1 more source

Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

, 2015
In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 ...
Cayuela, Jean-Michel, Huguet, Françoise, Maury, Sébastien, Chalandon, Yves, Lepretre, S., Ifrah, N., Berthon, C., Chevret, S., Escoffre-Barbe, Martine, Dombret, Hervé, Lepretre, Stéphane, Rousselot, Philippe, Thomas, X., Escoffre-Barbe, M., Maury, S., Tavernier, E., Hayette, Sandrine, Tavernier, Emmanuelle, Berthon, Céline, Lhéritier, V., Raffoux, E., Lafage-Pochitaloff, M., Cayuela, J.M., Abbal, C., Chalandon, Y., Thomas, Xavier, Leguay, Thibaut, Chevret, Sylvie, Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), Leguay, T., Rousselot, P., Lambert, Jean-François, Abbal, Claire, Hayette, S., Lafage-Pochitaloff, Marina, Lhéritier, Véronique, Huguet, F., Lambert, J.F., Raffoux, Emmanuel, Ifrah, Norbert, Dombret, H.   +40 more
core   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia

Haematologica, 2011
Background Despite incremental improvements in outcomes for patients with acute lymphoblastic leukemia, significant numbers of patients still die from this disease.
Philip Saunders, Adam Cisterne, Jocelyn Weiss, Kenneth F. Bradstock, Linda J. Bendall   +4 more
doaj   +1 more source