Results 61 to 70 of about 13,786,958 (257)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia

Haematologica, 2015
Multiparametric flow cytometry is an alternative approach to the polymerase chain reaction method for evaluating minimal residual disease in treatment protocols for primary acute lymphoblastic leukemia.
Leonid Karawajew, Michael Dworzak, Richard Ratei, Peter Rhein, Giuseppe Gaipa, Barbara Buldini, Giuseppe Basso, Ondrej Hrusak, Wolf-Dieter Ludwig, Günter Henze, Karl Seeger, Arend von Stackelberg, Ester Mejstrikova, Cornelia Eckert   +13 more
doaj   +1 more source

Acute lymphoblastic leukemia presenting with limping in a young adult

Clinical Case Reports, 2022
Acute lymphoblastic leukemia is one of the rare malignancies in adult. We report a 29‐year‐old man presented with progressive limping followed a chronic back pain. Imaging showed reduced vertebral body height and diffuse lytic skeletal infiltration. Bone
Mhd Baraa Habib, Bashar Tannos, Mohamed Abdelrazek, Mohamed A. Yassin   +3 more
doaj   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care

American Journal of Hematology, EarlyView.
ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali, Grace Elsey, Kayla Fulginiti, Zanette Kanani‐Bradley, Holly R. Kubaney, Sandra Kurtin, Theresa Nguyen, Jennifer Turchina, Charlotte B. Wagner   +8 more
wiley   +1 more source

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

Haematologica, 2015
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide ...
Setareh Safavi, Markus Hansson, Karin Karlsson, Andrea Biloglav, Bertil Johansson, Kajsa Paulsson   +5 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Algorithm of Hepatitis B Vaccinal Prevention at Children with Acute Lymphoblastic Leukemia in Dynamics of Program Therapy

Медицинский вестник Юга России, 2010
Purpose: To create the algorithm of hepatitis B vaccinal prevention at children with acute lymphoblastic leukemia. Materials and Methods: The data of 181 children with acute lymphoblastic leukemia, from which 99 patients received specific hepatitis B ...
N. V. Opaleva, E. V. Polevichenko, K. S. Aslanyan, V. V. Zotova, E. F. Efremova, L. D. Oreshkina, A. H. Haspekyan, I. V. Yachenko, E. V. Vasilieva, L. V. Goncharova, N. V. Krasnyanskaya, N. A. Golovanova, N. V. Mariina, N. G. Oginskaya, T. G. Kuruzyan, G. V. Erkina, T. N. Kalinina, A. M. Shaihutdinova   +17 more
doaj  

Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment.
Flávia Tobaldini Russo, Maria Cristina Martins de Almeida Macedo, Pedro Amoedo Fernandes, Larissa Yukari Okada, Lucas Augusto Monetta da Silva, Camila Menin Simões, Jamilla Neves Cavalcante, Aline de Almeida Simões, Manuella de Souza Sampaio Almeida, Maricy Almeida Viol Ferreira Lopes, Roberto Luiz da Silva   +10 more
doaj   +1 more source