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Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]
The Journal of Immunology, 2007 Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G, Tangye, Kim L, Good
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Annual Review of Cell and Developmental Biology, 2020 Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality.
Daniela, Frasca +4 more
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Transplantation, 2006 Autoreactive B cells are actively tolerized to more abundant self-antigens by a series of checkpoints involving receptor editing, deletion, anergy and competition for growth factors. In contrast, B cells reactive against rare, sequestered or tissue specific self-antigens remain functionally naïve.
Ferry, H +6 more
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Properties of regulatory B cells regulating B cell targets
American Journal of Transplantation, 2021 Regulatory B cells (Bregs) have shown promise as anti-rejection therapy applied to organ transplantation. However, less is known about their effect on other B cell populations that are involved in chronic graft rejection. We recently uncovered that naïve B cells, stimulated by TLR ligand agonists, converted into B cells with regulatory properties ...
Qiang Fu +11 more
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Immunological Reviews, 1975 SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
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Review 2: "Germline-targeting Chimpanzee SIV Envelopes Induce V2-apex Broadly Neutralizing-like 3 B Cell Precursors in a Rhesus Macaque Infection Model" [PDF]
, 2023 Cynthia A. Derdeyn
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The Journal of Immunology, 2015 In 1999, Stephen Nutt, Barry Heavey, Antonius Rolink, and Meinrad Busslinger unveiled how Pax5 masterminds B cell development ([1][1]). In doing so, they significantly deepened understanding about how competition between transcription factors can dictate cell fate.
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Japanese Journal of Clinical Immunology, 2009 B cells positively regulate immune responses through antibody production and optimal CD4(+) T cell activation. However, a specific and functionally important subset of B cells can also negatively regulate immune responses in mouse autoimmunity and inflammation models.
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Unique B cell responses in B cell-dependent and B cell-independent EAE
Autoimmunity, 2011 Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Guorong, Liu +3 more
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Advances in Hematology, 2012 Aggressive B-cell lymphomas (ABLs) are a group of B-cell malignancies, that is, a relatively common form of cancer across the world. This issue on aggressive B-cell lymphomas compiles 12 exciting manuscripts, most of which are very meticulously performed reviews of the available current literature.
Naresh KN +3 more
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