Results 261 to 270 of about 5,370,035 (306)
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Nature Reviews Immunology, 2015
The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte populations. Recent advances in tracking antigen-experienced memory B cells have revealed the existence of distinct classes of cells that have considerable functional differences. Some of these differences
Tomohiro, Kurosaki +2 more
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The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte populations. Recent advances in tracking antigen-experienced memory B cells have revealed the existence of distinct classes of cells that have considerable functional differences. Some of these differences
Tomohiro, Kurosaki +2 more
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Current Opinion in Immunology, 1992
Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates.
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Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates.
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Immunology Today, 1997
Abstract Superantigens (SAgs) are characterized by their ability to interact with T- and B-cell antigen (Ag) receptors outside of the classical Ag-binding groove. Here, Gress Silverman discusses the molecular basis for the binding of B-cell SAgs, and how they may influence the acquisition of immunocompetence or contribute to the development of immune ...
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Abstract Superantigens (SAgs) are characterized by their ability to interact with T- and B-cell antigen (Ag) receptors outside of the classical Ag-binding groove. Here, Gress Silverman discusses the molecular basis for the binding of B-cell SAgs, and how they may influence the acquisition of immunocompetence or contribute to the development of immune ...
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Immunology Today, 1981
The B cell population represents an extremely complex set of cells with respect to the existence of funclional and developmental cell subpopulations and their extremely diverse repertoire of antibody specificities. This article summarizes the key features of the ontogeny and developmental stages of murine B cells, the subjects of a recent extensive ...
N R, Klinman, D E, Wylie, J M, Teale
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The B cell population represents an extremely complex set of cells with respect to the existence of funclional and developmental cell subpopulations and their extremely diverse repertoire of antibody specificities. This article summarizes the key features of the ontogeny and developmental stages of murine B cells, the subjects of a recent extensive ...
N R, Klinman, D E, Wylie, J M, Teale
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2008
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
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The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
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2020
B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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Current Opinion in Immunology, 1992
Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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CD5 B Cells, a Fetal B Cell Lineage
1993Publisher Summary This chapter presents a short background of CD5 expression on B cells and focuses on the issue of the relationship of CD5 B cells to B cell development, proposing a model that views this subset as the progeny of a fetal B cell differentiation pathway.
R R, Hardy, K, Hayakawa
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FOXO in B-cell lymphopoiesis and B cell neoplasia
Seminars in Cancer Biology, 2018FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Alexey, Ushmorov, Thomas, Wirth
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