Results 161 to 170 of about 2,138,197 (387)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.

Blood, 2004
C. Hans, D. Weisenburger, T. Greiner, R. Gascoyne, J. Delabie, G. Ott, H. Müller-hermelink, E. Campo, R. Braziel, E. Jaffe, Zenggang Pan, Pedro Farinha, Lynette M. Smith, B. Falini, A. Banham, A. Rosenwald, L. Staudt, J. Connors, J. Armitage, W. Chan   +19 more
semanticscholar   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Axillary B-Cell Non-Hodgkin Lymphoma Mimicking Kikuchi Fujimoto Necrotising Lymphadenitis and Medullary Carcinoma of Breast

, 2023
Shinde Dipak Mahadeo Saiyam
openalex   +1 more source

T-Cell Receptor Dependent and Independent NF-kappa B Activation is a Prognostic Marker and a Therapeutic Target in Peripheral T-cell Lymphoma Not Otherwise Specified [PDF]

, 2022
Mohsen Navari, Maryam Etebari, Francesca Ricci, Pier Luigi Tazzari, Claudio Agostinelli, Philip Went, Davide Gibellini, Pier Paolo Piccaluga   +7 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Nature Medicine, 2018
B. Chapuy, C. Stewart, Andrew J. Dunford, Jaegil Kim, A. Kamburov, R. Redd, Mike S. Lawrence, M. Roemer, Amy Li, M. Ziepert, A. Staiger, J. Wala, M. Ducar, I. Leshchiner, Ester Rheinbay, A. Taylor-Weiner, C. Coughlin, J. Hess, C. Pedamallu, D. Livitz, D. Rosebrock, Mara W Rosenberg, A. Tracy, H. Horn, P. Van Hummelen, A. Feldman, B. Link, A. Novak, J. Cerhan, T. Habermann, R. Siebert, A. Rosenwald, A. Thorner, M. Meyerson, T. Golub, R. Beroukhim, G. Wulf, G. Ott, S. Rodig, S. Monti, D. Neuberg, M. Loeffler, M. Pfreundschuh, L. Trümper, G. Getz, M. Shipp   +45 more
semanticscholar   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Associations between gut microbiota and immune status in untreated B-cell lymphoma patients

Frontiers in Immunology
BackgroundEmerging evidence links gut microbiota to tumorigenesis via immune modulation, though subtype-specific microbial signatures in B-cell lymphomas remain unclear.
Jingxin Zhou, Jingxin Zhou, Jinrong Yao, Na Hu, Jing Su   +4 more
doaj   +1 more source