Results 31 to 40 of about 455,027 (266)

Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma

, 2016
An association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity.
Hohaus, Stefan, D'Alo', Francesco, Voso, Maria Teresa, Larocca, Luigi Maria, Bellesi, Silvia, Pompili, Maurizio, Maiolo, Elena, Tisi, Maria Chiara, Santangelo, Rosaria, Cupelli, Elisa, Giachelia, Manuela, Leone, Giuseppe, Alma, Eleonora, Martini, Maurizio   +13 more
core   +1 more source

miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma.

, 2020
Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment ...
Yébenes, Fuertes, Teresa, Ramiro, Almudena R, García-Yébenes Mena, Virginia Pilar   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular Pathogenesis of MALT lymphoma

, 2011
Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway.

core   +1 more source

Reproducibility of Gene Expression Signatures in Diffuse Large B-Cell Lymphoma [PDF]

, 2022
Multiple gene expression profiles have been identified in diffuse large B-cell lymphoma (DLBCL). Besides the cell of origin (COO) classifier, no signatures have been reproduced in independent studies or evaluated for capturing distinct aspects of DLBCL ...
van den Berg, Anke, Diepstra, Arjan; id_orcid, Pieternella J. Lugtenburg, Zijlstra, Josée, Lam, King, Marcel Nijland, Annika Seitz, Tjitske Los, Nijland, Marcel; id_orcid, van den Berg, Anke; id_orcid, Bauke Ylstra, King Lam, Wilson Araújo da Silva, Daphne de Jong, Plaça, Jessica Rodrigues, de Jong, Daphne, da Silva, Wilson Araújo, Seitz, Annika, Arjan Diepstra, Matías Mendeville, Lugtenburg, Pieternella J., Lugtenburg, Pieternella J, Anke van den Berg, Los, Tjitske, Ylstra, Bauke, Nijland, Marcel, Jessica Rodrigues Plaça, Diepstra, Arjan, Josée Zijlstra, Mendeville, Matías   +29 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Molecular diagnosis of malignant lymphoma : mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of malt [PDF]

, 2006
2006-01Malignant lymphoma is a heterogeneous category embracing three major types of lymphoid neoplasms: B cell neoplasms, T and NK cell neoplasms, and Hodgkin lymphoma.
Nakamura, Shigeo, 長坂, 徹郎, 榊原, 綾子, Kawai, Kumi, 下山, 芳江, Nagasaka, Tetsuro, 川井, 久美, Sakakibaya, Ayako, Shimoyama, Yoshie   +8 more
core   +1 more source