Results 191 to 200 of about 12,336,620 (246)

DNA Replication Stress‐Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center‐Derived B‐Lymphomagenesis

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).
Santosh Kumar Gothwal, Kyoko Oichai, Hongtae Kim, Kyungjae Myung, Jacqueline H. Barlow   +4 more
wiley   +1 more source

Papillary thyroid carcinoma in a patient with long-standing chronic lymphocytic leukemia: A case report. [PDF]

Oncol Lett
Ma J, Gan T, Song A, Tian H, Xu S, Zhao L.   +5 more
europepmc   +1 more source

Real‐World Determinants of Treatment Selection in Frontline Chronic Lymphocytic Leukemia: The FIRST‐CLL Study

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Multiple targeted agents are available for first‐line treatment of chronic lymphocytic leukemia (CLL), yet the absence of mature head‐to‐head comparisons makes treatment selection challenging. The prospective, multicenter FIRST‐CLL study evaluated real‐world treatment allocation, and the contribution of biological, clinical, logistical and ...
Francesca Perutelli, Matteo Arata, Raffaella Pasquale, Sara Pepe, Maura Nicolosi, Marina Deodato, Ilaria Piras, Erika Fioribello, Alessandro Bosi, Riccardo Moia, Andrea Ferrario, Michela Schirru, Elia Boccellato, Martina Bullo, Daniela Gottardi, Myriam Foglietta, Andrea Galitzia, Marta Coscia, Gianluca Gaidano, Michele Merli, Chiara Salvetti, Roberta Murru, Anna Maria Frustaci, Roberto Freilone, Jacopo Olivieri, Francesca Romana Mauro, Benedetto Bruno, Candida Vitale   +27 more
wiley   +1 more source

Zanubrutinib versus fludarabine, cyclophosphamide and rituximab in fit, treatment-naïve patients with chronic lymphocytic leukemia: a matching-adjusted indirect comparison. [PDF]

J Comp Eff Res
Munir T, Barnieh L, Mohseninejad L, Xu S, Jevdjevic M, Bouwmeester W, Yang K.   +6 more
europepmc   +1 more source

Optical Genome Mapping Reveals Frequent Cryptic Structural Aberrations in Normal Karyotype Acute Myeloid Leukemia

International Journal of Cancer, Volume 159, Issue 5, Page 1218-1227, 1 September 2026.
Acute myeloid leukemia adult cases often appear cytogenetically normal when analyzed with conventional karyotyping. However, acquired structural variants may escape routine detection. Here, optical genome mapping detected diverse genomic alterations in nearly half of the analyzed cytogenetically normal cases.
Tuuni Turtinen, Andriana Valkama, Christopher Wray, Sandra Vorimo, Hannele Räsänen, Eeva‐Riitta Savolainen, Katri Pylkäs, Tuomo Mantere   +7 more
wiley   +1 more source

Increased Frequency of the Chemokine Receptor CCR2 on Circulating CD19+CD5+ Lymphocytes in Therapy-Naïve CLL Patients With the Detectable EBV DNA and High-Avidity Antibodies Against the EBV Capsid Antigen. [PDF]

Can J Infect Dis Med Microbiol
Zvejniece L, Kozireva S, Nazarenko M, Kornilova O, Rivkina A, Lejniece S, Leonciks A, Murovska M, Kashuba E, Kholodnyuk I.   +9 more
europepmc   +1 more source

Population Pharmacokinetics and Dose De‐Escalation Regimens of Subcutaneous Vedolizumab in Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background Vedolizumab is a therapeutic antibody approved for the treatment of Crohn's disease and ulcerative colitis. The population pharmacokinetics (popPK) of intravenous (IV) administered vedolizumab have been described, but remain to be defined for subcutaneous (SC) administration.
S. I. Anjie, N. Vreman, K. B. Gecse, M. Löwenberg, G. R. D'Haens, R. A. A. Mathôt   +5 more
wiley   +1 more source

Rab GTPases drive ligand-independent NOTCH1 activation via altered endocytic trafficking in chronic lymphocytic leukemia. [PDF]

Hemasphere
De Falco F, Del Papa B, Sorcini D, Valmarini L, Adamo FM, Atzeni A, Esposito A, Silva Barcelos EC, Dorillo E, Stella A, Arcaleni R, Gurrieri F, Pugliese M, Astolfi G, Martelli MP, Di Ianni M, Rosati E, Sportoletti P.   +17 more
europepmc   +1 more source

Proteomic Atlas of Notochordal Cell‐Derived Extracellular Vesicles Highlights EV‐Specific NF‐κB Modulation and Functional Implications of the Protein Corona

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT The notochord is a central signalling hub during embryonic development. After regression of the notochord, notochordal cells (NCs) reside within the developing intervertebral disc. The NC‐secretome, including matrix, proteins and extracellular vesicles (NC‐EVs), promotes regeneration of degenerate intervertebral discs and cartilage. This study
Josette C. van Maanen, Chantal Voskamp, Frank M. Riemers, Harmjan R. Vos, Anouk Eversdijk, Marije Kleinjan, Menno Bergmeijer, Martijn J. C. van Herwijnen, Stuart C. Howes, Frances C. Bach, Tim J. M. Welting, Christine L. Le Maitre, Guus G. H. van den Akker, Marca H. M. Wauben, Mariana A. Tryfonidou   +14 more
wiley   +1 more source

Sequencing asymmetry: the case for caution before first-line pirtobrutinib in chronic lymphocytic leukemia. [PDF]

Ann Hematol
Chen B, Qian S.
europepmc   +1 more source