Results 201 to 210 of about 12,679,286 (241)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
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Topology and its Applications, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kunzi, H., Pajoohesh, H.
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zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kunzi, H., Pajoohesh, H.
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Revisiting graphical rectangular b-metric spaces
Asian-European Journal of Mathematics, 2021Very recently, the notion of graphical rectangular [Formula: see text]-metric spaces has been introduced, where the weight of the symmetric edges endowing the directed graph is defined in terms of the underlying metric. Due to its intimate relationship with the directed graphs, such spaces have a wide range of applications in science and engineering ...
Mudasir Younis, Deepak Singh, Luoyi Shi
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Topology and its Applications, 2020
In this paper, the authors introduce the notion of strong partial \(b\)-metric space and establish a number of completion results over such structures. The following are the main results of this exposition. \textbf{Theorem 1.} Every strong partial \(b\)-metric space \((X,\alpha,\sigma)\) admits a \(0\)-Cauchy completion \((X^*,\alpha,\sigma ...
Moshokoa, Seithuti, Ncongwane, Fanyana
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In this paper, the authors introduce the notion of strong partial \(b\)-metric space and establish a number of completion results over such structures. The following are the main results of this exposition. \textbf{Theorem 1.} Every strong partial \(b\)-metric space \((X,\alpha,\sigma)\) admits a \(0\)-Cauchy completion \((X^*,\alpha,\sigma ...
Moshokoa, Seithuti, Ncongwane, Fanyana
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Principles for the Design of Online A/B Metrics
Proceedings of the 39th International ACM SIGIR conference on Research and Development in Information Retrieval, 2016In this paper, we describe principles for designing metrics in the context of A/B experiments. We share some issues that comes up in designing such experiments and provide solutions to avoid such pitfalls.
Widad Machmouchi, Georg Buscher
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2014
In 1993 another axiom for semimetric spaces, which is weaker than the triangle inequality, was put forth by Czerwik [58] with a view of generalizing the Banach contraction mapping theorem. This same relaxation of the triangle inequality is also discussed in Fagin et al. [79], who call this new distance measure nonlinear elastic matching (NEM).
William Kirk, Naseer Shahzad
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In 1993 another axiom for semimetric spaces, which is weaker than the triangle inequality, was put forth by Czerwik [58] with a view of generalizing the Banach contraction mapping theorem. This same relaxation of the triangle inequality is also discussed in Fagin et al. [79], who call this new distance measure nonlinear elastic matching (NEM).
William Kirk, Naseer Shahzad
openaire +1 more source
Remarks on b-Metric and metric-preserving functions
Mathematica Slovaca, 2018Abstract We introduce new classes of functions related to metric-preserving functions and b-metrics. We investigate their properties and compare them to those of metric-preserving functions.
Khemaratchatakumthorn, Tammatada +1 more
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