Results 41 to 50 of about 16,369,324 (285)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Application of Quasi-Uniform B-Spline Surfaces with Different Degrees to Mesoscale Eddy Fitting

Remote Sensing
Satellite altimetry technology provides along-track sea level anomaly (SLA) data for studying mesoscale eddies. However, accurately reconstructing their spatial structures from discrete and non-uniform along-track observations remains a significant ...
Chunzheng Kong, Chuanfeng Liu, Wei Zhou, Xianqing Lv   +3 more
doaj   +1 more source

Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys

Advanced Science, EarlyView.
This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin, Cheng‐Wei Lee, Nate S.P. Bernstein, Thi Nguyen, Ande Bryan, Eli Cooper, John S. Mangum, Sage R. Bauers, Andriy Zakutayev, Keisuke Yazawa, Prashun Gorai, Rebecca W. Smaha   +11 more
wiley   +1 more source

Parametric Surface Modelling for Tea Leaf Point Cloud Based on Non-Uniform Rational Basis Spline Technique

Sensors, 2021
Plant leaf 3D architecture changes during growth and shows sensitive response to environmental stresses. In recent years, acquisition and segmentation methods of leaf point cloud developed rapidly, but 3D modelling leaf point clouds has not gained much ...
Wenchao Wu, Yongguang Hu, Yongzong Lu
doaj   +1 more source

Physics‐Constrained Constitutive Learning of Rate‐Limiting Timescales for Efficient Hydrogen‐Based Direct Reduction for Green Steel Making

Advanced Science, EarlyView.
A conversion‐resolved constitutive framework is developed for the hydrogen‐based direct reduction of iron oxide pellets. Effective reaction and transport timescales are inferred directly from measured trajectories and mapped against operating conditions, pellet architecture, and composition. The analysis reveals how late‐stage transport control emerges
Anurag Bajpai, Barak Ratzker, Pasquale Cavaliere, Dierk Raabe   +3 more
wiley   +1 more source

A Reconstruction Algorithm for Blade Surface Based on Less Measured Points

International Journal of Aerospace Engineering, 2015
A reconstruction algorithm for blade surface from less measured points of section curves is given based on B-spline surface interpolation. The less measured points are divided into different segments by the key geometric points and throat points which ...
Jia Liu, Ji Zhao, Xu Yang, Jiming Liu, Xingtian Qu, Xin Wang   +5 more
doaj   +1 more source

Physics‐Informed Neural Network‐Enabled Forward Prediction and Inverse Design of Ring Origami

Advanced Science, EarlyView.
This work presents a KRT‐PINN framework that integrates Kirchhoff rod theory with physics‐informed neural networks for the forward prediction and inverse design of ring origami consisting of closed‐loop rods. The framework predicts stable states of segmented rings with prescribed natural‐curvature profiles and determines the natural‐curvature profiles ...
Luyuan Ning, Lu Lu, Sophie Leanza, Ruike Renee Zhao   +3 more
wiley   +1 more source

Modeling technology of curved surface development for puffer fish

Advances in Mechanical Engineering, 2020
The drag reduction mechanism of puffer epidermis was closely related to its real geometry. In order to solve the modeling problem of epidermal spines on the puffer surface, a modeling method for the expansion of puffer shape was proposed.
Honggen Zhou, Jie Cui, Guizhong Tian, Yesheng Zhu, Changfeng Jia   +4 more
doaj   +1 more source

An Approach To 3D Surface Curvature Analysis [PDF]

Engineering and Technology Journal, 2005
This paper reviews the graphical tools available for checking the quality of CAD/CAM (Computer Aided Design / Manufacture) surface models (B-Spline form).
Laith Mohammed
doaj   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source