Results 51 to 60 of about 16,369,324 (285)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Measurement point sampling method for inspection of parts with free-form surfaces

open access: yesAdvances in Mechanical Engineering, 2018
Parts must be measured to evaluate the manufacturing accuracy in order to check whether their dimension is in expected tolerance. In engineering, parts with free-form surfaces are generally measured by high-precision coordinate-measuring machines.
Dezhong Zhao   +5 more
doaj   +1 more source

EndoTac: An Endoscopic Camera‐Based Tactile Sensor with High Sensitivity for Minimally Invasive Surgery

open access: yesAdvanced Science, EarlyView.
EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang   +5 more
wiley   +1 more source

Approximation with active B-spline curves and surfaces [PDF]

open access: yes10th Pacific Conference on Computer Graphics and Applications, 2002. Proceedings., 2003
An active contour model for parametric curve and surface approximation is presented. The active curve or surface adapts to the model shape to be approximated in an optimization algorithm. The quasi-Newton optimization procedure in each iteration step minimizes a quadratic function which is built up with the help of local quadratic approximants of the ...
Helmut Pottmann   +2 more
openaire   +3 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

open access: yesAdvanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni   +17 more
wiley   +1 more source

Research on the Nonlinear Stiffness Characteristics of Spline Coupling Under Multiple Contact Surfaces

open access: yesMachines
Spline couplings endure various external loads during operation, which induce complex variations in contact surfaces and significantly affect their stiffness behavior. This research focuses on a specific spline coupling to analyze its nonlinear stiffness
Chongbei Huang, Yinli Feng
doaj   +1 more source

Sculptured Surface Design and Implementation by Lofting Design Method Using Cross-sectional B-Spline Curves

open access: yesAl-Khawarizmi Engineering Journal, 2019
This research presents a particular designing strategy for a free form of surfaces, constructed by the lofting design method. The regarded surfaces were created by sliding a B-spline curves (profile curves), in addition to describing an automatic ...
Wisam Kadhum Hamdan   +1 more
doaj   +1 more source

B-Spline Surface Fitting on Scattered Points [PDF]

open access: yes, 2016
This paper looks into the effectiveness of B-spline approximation algorithm in approximating the bicubic B-spline surface from the set of scattered data points which are taken from the scanned 3D object in the form of point sets.
Abd. Majid, Ahmad   +2 more
core   +1 more source

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

open access: yesAdvanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg   +19 more
wiley   +1 more source

基于均匀三次B样条曲面的斜齿轮副精确建模

open access: yesJixie chuandong, 2012
The accurate surface of helical gear tooth is established based on cubic uniform B-spline method.With the tooth surface,the solid assembly model of helical gear pair is realized on ANSYS,which ensure the reliability and accuracy of finite element contact
李学艺   +3 more
doaj  

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