Results 171 to 180 of about 45,072 (266)

Influence of Continuous Predictor Modelling Methods on Prediction Stability in Clinical Prediction Model Development: An Empirical Comparison Using Real Clinical Data. [PDF]

Clin Epidemiol
Phinyo P, Wongyikul P, Jirattikanwong N, Isaradech N, Kiratipaisarl W, Lawanaskol S, Seesuwan N, Sirikul W.   +7 more
europepmc   +1 more source

Quantifying Actin Persistence Length in S. pombe and S. cerevisiae: The Impact of Data Size, Filament Length and Fitting Strategy

Cytoskeleton, EarlyView.
ABSTRACT Actin filaments exhibit isoform and species‐specific mechanical properties that are commonly quantified via their persistence length, yet the reliability of such measurements depends not only on the analysis method but also on dataset characteristics.
Peter Nietmann, Andrejus Suchenko, Andreas Janshoff, Mohan K. Balasubramanian   +3 more
wiley   +1 more source

Risk factors for scaphoid nonunion in acute fractures treated with cast immobilization. [PDF]

Bone Jt Open
Dean BJF, Saedi F, Riley ND, Ather S, Tsegaye B, Dhiman P, Oxford Scaphoid Study Group, Little C, Sheehan W, Costa ML.   +9 more
europepmc   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Exploratory multivariate adaptive regression splines modeling of myopic progression in children receiving atropine. [PDF]

J Chin Med Assoc
Chen JW, Yu CH, Liu TC, Lu CJ, Wu TE.
europepmc   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Pre- and Immediate Postoperative Prediction Model for Organ Dysfunction or Death Early After Cardiac Surgery: A Post Hoc Analysis of a Multicenter Randomized Trial. [PDF]

J Am Heart Assoc
Dresen E, Heyland DK, Lee ZY, O'Brien B, Elke G, Radke DI, Meybohm P, Schoenrath F, Sündermann SH, von Dossow V, McDonald B, Christopher KB, Fremes SE, Mohammadi S, Niemann B, Böning A, Mazer CD, Ke L, Zarbock A, Day AG, Stoppe C.   +20 more
europepmc   +1 more source

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot   +8 more
wiley   +1 more source