Results 131 to 140 of about 24,435,209 (289)
Dizhen xuebao使用云南地震台网2009—2021年的地震目录和波形数据，采用双差定位方法、基于P波初动极性和S/P振幅比的HASH方法和最大似然法等，获取了维西—乔后断裂带及附近地区ML≥4.0震群和前震序列精确的震源位置、震源机制解、视应力和b值等地震活动参数，对比分析了维西—乔后断裂带及其周边震群及前震序列的活动特征。结果显示：除前震序列频次呈现出反大森定律外，前震序列与普通震群在空间分布、震源机制一致性、视应力和b值等单一参数方面并无明显的差异；但前震序列同时具备震中优势分布方向与区域主要构造展布方向一致 ...
Guangming Wang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Archives of AcousticsIn order to research the acoustic emission characteristics of polypropylene fiber-reinforced recycled aggregate concrete under uniaxial load, 20 groups of test specimens with a coarse aggregate substitution rate of 25 % and 50 % are designed and ...
Daowen ZHOU +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Characteristics of acoustic emission ringing count-b value of sandstone.
Characteristics of acoustic emission ringing count-b value of sandstone.
Jiang Liu (197069) +6 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Value Co-Creation in B-to-B Networks
, 2010 The purpose of the research is to increase knowledge on value co-creation within b-to-b networks. The research strategy employed is a qualitative multiple-case study.
Jaakkola, Elina, Hakanen, Taru
core +1 more source