Results 31 to 40 of about 12,189,223 (218)

Monoclonal antibodies as tools in antigen detection assay and vaccine development : design of a sensitive detection test for Brucella bacteria and profiling of the malaria vaccine candidate antigen reticulocyte-binding homolog 2 (PfRH2) [PDF]

, 2015
We aimed at identifying immunodominant Brucella antigens for implementation in new detection tools or for subunit vaccine development. In particular, our strategy was to produce Brucella cell surface antigen-specific monoclonal antibodies (mAbs) for the ...
Silbereisen, Angelika
core   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

A Wzx-Wzy-like Polysaccharide Biosynthetic Pathway Contributes to Virulence in Brucella abortus 2308 through an Unknown Mechanism

, 2023
Brucella abortus is an intracellular pathogen that causes spontaneous abortion in cattle and undulant fever in humans. As a member of the a-proteobacteria, B.
NC DOCKS at East Carolina University, Hopersberger, Dariel Anne   +1 more
core   +1 more source

The development of immunoassays for the detection of bovine brucellosis and aflatoxin B1 [PDF]

, 2004
The research discussed in this thesis focuses on the development and characterisation of immunoassays for the detection of aflatoxin Bi (AFBi), a toxic fungal metabolite, and for the diagnosis of bovine brucellosis, a highly contagious disease of cattle ...
Dunne, Lynsey
core   +2 more sources

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Frontiers in Immunology, 2023
ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Usevich Vera Nikolaevna, Suleimenov Maratbek, Suleimenov Maratbek, Zhen Wang, Hui Zhang   +15 more
doaj   +1 more source

The impact of bvdv infection on the immune efficacy of brucella abortus a19 vaccine [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
As Bovine Viral Diarrhea Virus (BVDV) is widespread in cattle and often causes immunosuppression, it is essential to evaluate whether it interferes with the effectiveness of widely used live vaccines such as Brucella abortus A19. This study evaluated the
Yingjin CHAI, Yidan ZHANG, Jiahui ZHANG, Jia GUO, Hui ZHANG   +4 more
doaj   +1 more source

Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus [PDF]

BMC Microbiology, 2016
Brucella abortus is an intracellular pathogen which can infect and persist in host cells through multiple interactions. Above all, its interaction to host cell receptor is important to understand the pathogenic mechanisms of B. abortus. Accordingly, we demonstrated that platelet-activating factor receptor (PAFR) affects host cell response against B ...
Lee, Jin Ju, Simborio, Hannah Leah, Reyes, Alisha Wehdnesday Bernardo, Hop, Huynh Tan, Arayan, Lauren Togonon, Lee, Hu Jang, Min, Wongi, Her, Moon, Rhee, Man Hee, Watarai, Masahisa, Chang, Hong Hee, Kim, Suk   +11 more
openaire   +2 more sources

Pesquisa de anticorpos anti-Brucella abortus e anti-Brucella ovis em ovinos no município de Uberlândia, MG

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2011
The first epidemiologic inquiry to Brucella abortus (B. abortus) and Brucella ovis (B. ovis) was carried out in sheep from Uberlândia county, MG. A total of 334 blood serum samples of sheep from both sexes and different ages and breeds were collected in ...
S.R.S. Salaberry, L.M. Paulin, R.L. Santana, J.R. Castro, A.M.C. Lima-Ribeiro   +4 more
doaj   +1 more source

Characterisation of Brucella species and biovars in South Africa between 2008 and 2018 using laboratory diagnostic data

Veterinary Medicine and Science, 2021
Background Brucellosis is an infectious zoonotic bacterial disease of humans and other animals. In the Republic of South Africa (RSA), animal brucellosis is widespread and the current available data on the prevalence of this disease rely solely on ...
Itumeleng Matle, Betty Ledwaba, Karabelo Madiba, Lavhelesani Makhado, Kudakwashe Jambwa, Nombasa Ntushelo   +5 more
doaj   +1 more source

Brucella abortusRB51 Induces Protection in Mice Orally Infected with the Virulent StrainB. abortus2308 [PDF]

Infection and Immunity, 2003
ABSTRACTBrucellae are gram-negative, facultative intracellular bacteria which are one of the most common causes of abortion in animals. In addition, they are the source of a severe zoonosis. In this trial, we evaluated the effect of oral inoculation ofBrucella abortusRB51 in mice against a challenge infection withB. abortus2308. First, we showed that a
Paolo, Pasquali, Adone, Rosanna, Claudia, Pistoia, Paola, Petrucci, Franco, Ciuchini   +4 more
openaire   +2 more sources