Results 341 to 350 of about 29,942,317 (406)
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CD5 B cells and B-cell malignancies
Current Opinion in Hematology, 1999Over the past year, progress has been made in understanding of the physiology and disease associations of CD5+ (B1) B cells, although their exact role in pathogenesis remains unclear. Earlier studies on the negative function of CD5 within the B-cell receptor complex have been substantiated, and it seems likely that soon the signaling pathways used by ...
P M, Lydyard +3 more
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2020
B cells are typically characterized by their ability to produce antibodies, function as secondary antigen-present cells, and produce various immunoregulatory cytokines. The regulatory B (Breg)-cell population is now widely accepted as an important modulatory component of the immune system that suppresses inflammation.
Luman, Wang, Ying, Fu, Yiwei, Chu
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B cells are typically characterized by their ability to produce antibodies, function as secondary antigen-present cells, and produce various immunoregulatory cytokines. The regulatory B (Breg)-cell population is now widely accepted as an important modulatory component of the immune system that suppresses inflammation.
Luman, Wang, Ying, Fu, Yiwei, Chu
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Current Opinion in Immunology, 1995
Recent studies have identified CD40 ligand (CD40L) as the critical membrane-expressed molecule responsible for T cell dependent B-cell activation. CD40L co-operates with various cytokines to induce B-cell activation, proliferation, and immunoglobulin isotype switching.
R J, Armitage, M R, Alderson
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Recent studies have identified CD40 ligand (CD40L) as the critical membrane-expressed molecule responsible for T cell dependent B-cell activation. CD40L co-operates with various cytokines to induce B-cell activation, proliferation, and immunoglobulin isotype switching.
R J, Armitage, M R, Alderson
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Clinical and Experimental Immunology, 2022
The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just
Jo Spencer, Mats Bemark, Thomas J Tull
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The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just
Jo Spencer, Mats Bemark, Thomas J Tull
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Rheumatic Disease Clinics of North America, 2004
In recent years, our understanding of B-cell biology and the roles of B cells in normal immune responses and autoimmunity has increased dramatically. We no longer think of B cells simply as antibody factories. It is clear that these diverse and exquisitely regulated cells may contribute in a multitude of ways to immune responses.
Elena, Weinstein +3 more
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In recent years, our understanding of B-cell biology and the roles of B cells in normal immune responses and autoimmunity has increased dramatically. We no longer think of B cells simply as antibody factories. It is clear that these diverse and exquisitely regulated cells may contribute in a multitude of ways to immune responses.
Elena, Weinstein +3 more
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2018
Mucosal B cells are crucial for host defense. The mucosal surfaces exceed 300 m2 in humans and represent indeed the largest part of the body in which immune responses take place daily. Mucosal B cells, located in the gut, respiratory, and urogenital mucosae as well as in skin, salivary, mammary, and lacrimal glands, are very important to protect ...
TROILO, A. +4 more
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Mucosal B cells are crucial for host defense. The mucosal surfaces exceed 300 m2 in humans and represent indeed the largest part of the body in which immune responses take place daily. Mucosal B cells, located in the gut, respiratory, and urogenital mucosae as well as in skin, salivary, mammary, and lacrimal glands, are very important to protect ...
TROILO, A. +4 more
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Current Opinion in Immunology, 1992
Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates.
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Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates.
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Immunology Today, 1997
Abstract Superantigens (SAgs) are characterized by their ability to interact with T- and B-cell antigen (Ag) receptors outside of the classical Ag-binding groove. Here, Gress Silverman discusses the molecular basis for the binding of B-cell SAgs, and how they may influence the acquisition of immunocompetence or contribute to the development of immune ...
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Abstract Superantigens (SAgs) are characterized by their ability to interact with T- and B-cell antigen (Ag) receptors outside of the classical Ag-binding groove. Here, Gress Silverman discusses the molecular basis for the binding of B-cell SAgs, and how they may influence the acquisition of immunocompetence or contribute to the development of immune ...
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Immunology Today, 1981
The B cell population represents an extremely complex set of cells with respect to the existence of funclional and developmental cell subpopulations and their extremely diverse repertoire of antibody specificities. This article summarizes the key features of the ontogeny and developmental stages of murine B cells, the subjects of a recent extensive ...
N R, Klinman, D E, Wylie, J M, Teale
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The B cell population represents an extremely complex set of cells with respect to the existence of funclional and developmental cell subpopulations and their extremely diverse repertoire of antibody specificities. This article summarizes the key features of the ontogeny and developmental stages of murine B cells, the subjects of a recent extensive ...
N R, Klinman, D E, Wylie, J M, Teale
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2008
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
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The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
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