Results 351 to 360 of about 29,942,317 (406)
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2020
B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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Lupus, 2002
This session had as its central theme the analysis of peptide epitopes and their relationship with lupus pathogenesis. New information on the role of peptides opens up the possibility of treatments based on inducing immunological tolerance although care needs to be taken since it is diffi cult to predict flare or remission of disease after exposure to
M R, Ehrenstein, B, Hahn
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This session had as its central theme the analysis of peptide epitopes and their relationship with lupus pathogenesis. New information on the role of peptides opens up the possibility of treatments based on inducing immunological tolerance although care needs to be taken since it is diffi cult to predict flare or remission of disease after exposure to
M R, Ehrenstein, B, Hahn
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Current Opinion in Immunology, 1992
Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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CD5 B Cells, a Fetal B Cell Lineage
1993Publisher Summary This chapter presents a short background of CD5 expression on B cells and focuses on the issue of the relationship of CD5 B cells to B cell development, proposing a model that views this subset as the progeny of a fetal B cell differentiation pathway.
R R, Hardy, K, Hayakawa
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2004
Publisher Summary B-lymphocytes provide the humoral (antibody-mediated) arm of the adaptive immune system. Like all leukocytes, B cells develop from hematopoietic stem cells in the bone marrow. The bone marrow is a tissue where B cells of all developmental stages can be isolated.
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Publisher Summary B-lymphocytes provide the humoral (antibody-mediated) arm of the adaptive immune system. Like all leukocytes, B cells develop from hematopoietic stem cells in the bone marrow. The bone marrow is a tissue where B cells of all developmental stages can be isolated.
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B-cell receptor regulation of peripheral B cells
Current Opinion in Immunology, 1998Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing
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B cells, plasma cells and antibody repertoires in the tumour microenvironment
Nature reviews. Immunology, 2020G. Sharonov +4 more
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Nature Reviews Immunology, 2004
The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
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The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
openaire +2 more sources