Results 71 to 80 of about 5,786,533 (245)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Synergistic effect of waste-derived β-tricalcium phosphate microbeads loaded in hydroxyapatite-keratin-polyvinyl alcohol composite matrix in drug release for osteosarcoma treatment

Future Journal of Pharmaceutical Sciences
Background Sustained drug delivery system (DDS) for clinically relevant osteosarcoma medications is a promising strategy for treatment. β-tricalcium phosphate (β-TCP) microbeads loaded with doxorubicin hydrochloride (DOX) and cis-diamminedichloroplatin ...
Himanshi Diwan, Siddhartha Dan, Mahesh Kumar Sah   +2 more
doaj   +1 more source

Relationship between consumer acquisition efforts and consumer loyalty

Kelaniya Journal of Management, 2016
Consumer Relationship Management is an integrated approach to manage long-term consumer relationships by implementing the practices of right acquisition and retention efforts.
Jagwinder Singh, Shivani Saini
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Urging health collaboration to combat antimicrobial resistance between China and B&R countries. [PDF]

Infect Dis Poverty, 2022
Cheng Z, Zhou N, Zhang X, Lv C, Guo X, Zhu Y, Li M.   +6 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quantifying the Spatial Sustainability Threshold of Conventional Potato Distribution Logistics [PDF]

E3S Web of Conferences
While the environmental effects of agricultural development are widely understood, the ecological cost associated with the regional distribution of substantial supplies in emerging countries is still a major unknown.
Bhardwaj Arvind, Kumar Rohit, Singh Lakhwinder Pal, Singh Gurraj   +3 more
doaj   +1 more source

Ladies Are So Essential in Research (LASER). [PDF]

JACS Au, 2023
Sivells T, Checinski CJ, Musegades LJ, Barnum E, Cyran JD.   +4 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Design of the Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor Versus Placebo in Patients With Congenital Systemic Right Ventricle Heart Failure (PARACYS-RV) Trial. [PDF]

CJC Open, 2023
Chaix MA, Dore A, Mondésert B, Mongeon FP, Roy V, Guertin MC, White M, Ibrahim R, O'Meara E, Rouleau JL, Khairy P, PARACYS-RV investigators.   +11 more
europepmc   +1 more source