Results 81 to 90 of about 5,786,533 (245)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Exploring water hardness removal potential of halotolerant bacteria isolated and characterized from brine lemon pickle

Frontiers in Environmental Engineering
IntroductionHalotolerant microorganisms capable of thriving in high salt concentrations are of significant interest due to their ecological roles and potential industrial applications. This study aimed to isolate and characterize a halotolerant bacterial
Shivani Chauhan, Simranpreet Kaur, Sundeep Kaur, Sumer Singh Meena, Anee Mohanty   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Selenium at the Neural Barriers: A Review. [PDF]

Front Neurosci, 2021
Solovyev N, Drobyshev E, Blume B, Michalke B.   +3 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An Alternate for F. R. B. R.?

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2014
Purpose: The aim of this article is to propose an alternate for F.R. B.R. Methodology: The methodology is based on library investigation and Web searching. Findings: In this article every bibliographical entity is studied from eight approaches: the first is ontological one which deals with three equal - valued elements with which the entity comes into ...
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Altered Default Mode Network Is Associated With Cognitive Impairment in CADASIL as Revealed by Multimodal Neuroimaging. [PDF]

Front Neurol, 2021
Li P, Huang Q, Ban S, Qiao Y, Wu J, Zhai Y, Du X, Hua F, Su J.   +8 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Calculating plastic viscosity of self-compacting concrete using V-funnel time: a novel mathematical approach with calibration using coefficient of viscosity

Discover Civil Engineering
The plastic viscosity (µ) of Self-Compacting Concrete (SCC) is a fundamental rheological property governing its flowability, passing ability, and segregation resistance.
Tejinderpal Singh, Ran Bir Singh, Kanish Kapoor, S. P. Singh   +3 more
doaj   +1 more source