Results 61 to 70 of about 692,088 (326)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Metabolite Profiling for Six 'B' Vitamins Using LC-MS in Tomato Genotypes at Different Stages of Fruit Maturity [PDF]

open access: yes, 2015
Vitamins are essential nutrients in food crucial for maintaining good health. Tomato, being a widely consumed vegetable, provides a good quantity of vitamins. Metabolite profiling of vitamins at different stages of fruit maturity in a crop helps identify
Kavitha, P   +7 more
core   +2 more sources

Bone‐wise rigid registration of femur, tibia, and fibula for the tracking of temporal changes

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Multiple myeloma (MM) induces temporal alterations in bone structure, such as osteolytic bone lesions, which are challenging to identify through manual image interpretation. The large variation in radiologists' assessments, even at expert centers, further complicates diagnosis.
Arttu Ruohola   +5 more
wiley   +1 more source

Pain reliever combinations in treatment of patients with acute musculoskeletal back pain

open access: yesНеврология, нейропсихиатрия, психосоматика, 2021
Objective: to compare the clinical efficacy of complex therapy, including a combination of a nonsteroidal anti-inflammatory drug (NSAID) with a muscle relaxant and B vitamins in acute musculoskeletal back pain (MSBP).Patients and methods.
R. V. Gorenkov   +3 more
doaj   +1 more source

Vitamin K content of Australian-grown horticultural commodities [PDF]

open access: yesFood Chem. 452:139382 (2024)
Vitamin K is emerging as a multi-function vitamin that plays a role in bone, brain and vascular health. Vitamin K composition data remain limited globally and Australia has lacked nationally representative data for vitamin K1 (phylloquinone, PK) in horticultural commodities.
arxiv   +1 more source

Clinical principles for the diagnosis and treatment of musculoskeletal (non-specific) lower back pain

open access: yesНеврология, нейропсихиатрия, психосоматика, 2021
Low back pain (LBP) is one of the most common reasons for a neurologist visit. In 90–95% of cases, LBP is nonspecific (musculoskeletal). The diagnosis of nonspecific LBP based on symptoms, somatic and neurological examination data, the absence of «red ...
V. A. Golovacheva   +2 more
doaj   +1 more source

Validation of hplc methods for analysis of vitamins B1, B2, B6 and niacin naturally present in cereal flours [PDF]

open access: yes, 2008
Complex B vitamins are present in some cereal foods and the ingestion of enriched products contributes to the recommended dietary intake of these micronutrients.
ALMEIDA-MURADIAN, Ligia Bicudo de   +1 more
core   +2 more sources

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro   +12 more
wiley   +1 more source

Facts About Folate

open access: yesEDIS, 2018
Everyone needs folate. It is especially important for women who can become pregnant. Pregnant and nursing women, growing children, and older adults also need plenty of folate. This 2-page fact sheet is a major revision that discusses folate requirements,
Linda B Bobroff
doaj  

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