Results 61 to 70 of about 13,872,756 (390)

The effectiveness of the combined preparation of NSAIDs with B vitamins in diseases of the musculoskeletal system

Лечащий Врач, 2021
The purpose of this open, not comparative study was to evaluate the efficacy and safety of pain therapy for diseases of the musculoskeletal system. The study included 30 patients with joint pain of different localization who are hospitalized in the ...
A. L. Kebina, A. S. Sycheva, S. V. Shustova, A. L. Vertkin   +3 more
doaj   +1 more source

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial [PDF]

, 2014
Background: B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke.
Al-Tahan, Aminoff, Aminoff, Donato, Fyfe, Grarup, Grasbeck, Hazra, Hazra, Hsu, Imerslund, Kamatani, Kirsch, Koury, Krintel, Kristiansen, Laurie, Lee, Li, Lin, Manichaikul, Matchar, McDowell, Nguyen, Ntaios, Owczarek-Lipska, Pennypacker, Pruim, Rajan, Reynolds, Selhub, Spence, Spinneker, Stabler, Stone, Stover, Tanaka, Tanner, Toole, Toole, Toprak, Van Den Bossche, Vardy, Wald, Wang, Wang, Webb, Yetley   +47 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins

International Journal of Molecular Sciences, 2019
DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer’s disease (LOAD). Methylenetetrahydrofolate reductase (MTHFR) gene mutations occur in most elderly patients with memory loss.
G. Román, Oscar Mancera-Páez, Camilo Bernal   +2 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Longitudinal follow–up of chronic hemodialysis patients without vitamin supplementation [PDF]

, 1986
Longitudinal follow–up of chronic hemodialysis patients without vitamin supplementation. Vitamin supplementation for dialysis patients is still controversial.
Boyce, H. Worth, Brueggemeyer, Carl D., Butcher, Doris E., Chen, Marianne, Fuller, Suzanne M., Ganguly, Rama, Ramirez, German   +6 more
core   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Management of acute nonspecific lumbosacral pain: modern guidelines and new approaches in pharmacotherapy

Медицинский совет, 2019
Acute nonspecific lumbosacral pain (LSP) is one of the most common reasons people visit their doctor. This disease has a favourable prognosis, however, the low back pain can progress to a chronic course, if the treatment is inadequate.
V. A. Golovacheva, V. A. Parfenov
doaj   +1 more source

Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins

Frontiers in Physiology, 2019
Mitochondria are cellular organelles that control metabolic homeostasis and ATP generation, but also play an important role in other processes, like cell death decisions and immune signaling.
Joëlle J E Janssen, S. Grefte, J. Keijer, V. D. de Boer   +3 more
semanticscholar   +1 more source

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source