Results 71 to 80 of about 869,797 (265)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Study of effects of different plant growth regulators on explant's establishment of Aloe vera (Aloe barbadensis Mill.) [PDF]

فیزیولوژی محیطی گیاهی, 2010
Aloe (Aloe barbadensis Mill) is one of the most important medicinal plants belonging to Liliaceae family that nowadays is propagated by in vitro culture in high-scale propagation.
A.B Barzgar, M Shafiee HajiAbad, M Abdy
doaj  

The effect of benzyladenine and naphthalene acetic acid on rooting and subsequent growth of Portulaca umbraticola Kunth

Folia Horticulturae, 2010
Portulaca umbraticola Kunth stem cuttings were treated with BA or BA and NAA in different concentrations. BA was applied by spraying or by the quick-dip method.
Wróblewska Katarzyna, Bąbelewski Przemysław   +1 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Students waiting, BA Building fire drill, 1982

, 1982
Fire drill for the Business Arts Building (BA), 29 October ...
Swinburne Technical College
core   +1 more source

An Interview About The History of The Ba Clan in Brikama (NCAC_RDD_TAPE_1037A)

, 2023
Informant's genealogy Migration from Sierra Leone Alternative names: Ba, Baba, Galleh, Kalleh, Kalle, Darbo, Darboe, Dabo, Daboe, Konteh ...
NCAC/RDD
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Informal Structure of Senpai (Seniors), Kohai (Juniors), and Doki (Peers) in Japanese Organizations

Encyclopedia
In Japanese organizations, those who join earlier are called senpai (seniors), those who join later are kohai (juniors), and those who join in the same year are called doki (peers).
Tomoki Sekiguchi, Megumi Ikeda
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source