Results 81 to 90 of about 537,633 (307)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Bounds on internal state variables in viscoplasticity [PDF]

open access: yes
A typical viscoplastic model will introduce up to three types of internal state variables in order to properly describe transient material behavior; they are as follows: the back stress, the yield stress, and the drag strength.
Freed, Alan D.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Formulation of Subsequent Creep Considering Equivalance of Back Stress.

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 2000
Interaction between plastic and creep deformation is an important matter to construct a constitutive model for viscoplasticity. Praticularly, equivalence of back stress affecting plastic deformation and affecting creep deformation takes an important role to descreibe cyclic viscoplastic deformation by a constitutive model. In this paper, to clarify the
Katsuhiko SASAKI   +2 more
openaire   +1 more source

A constitutive model with damage for high temperature superalloys [PDF]

open access: yes
A unified constitutive model is searched for that is applicable for high temperature superalloys used in modern gas turbines. Two unified inelastic state variable constitutive models were evaluated for use with the damage parameter proposed by Kachanov ...
Sherwood, J. A., Stouffer, D. C.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Potential of oil-lubricated cylindrical plastic gears

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Bending strength of injection molded polyacetal test gears is investigated in back-to-back testing using oil-lubrication. To validate state of the art calculation methods, tooth geometries with a variable number of teeth are investigated, maintaining a ...
Christian HASL   +4 more
doaj   +1 more source

Closed form solution of the return mapping algorithm in elastoplasticity [PDF]

open access: yes, 2017
In the present work a return mapping algorithm is discussed for small strain elastoplasticity boundary value problems with an exact closed form solution of the local constitutive equations.
De Angelis, Fabio, Taylor, Robert L.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Reduced integral scheme of damaged divided back stress elasto plastic model based on full implicit algorithm

open access: yesNihon Kikai Gakkai ronbunshu, 2015
The purpose of this study is formulating the reduced integration method of damage elasto plastic constitutive model with divided back stress based on full implicit framework.
Shogo SANNOMARU   +2 more
doaj   +1 more source

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