Results 71 to 80 of about 569,561 (310)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Tunnel Back Analysis Based on Differential Evolution Using Stress and Displacement
Advances in Civil Engineering, 2020 The stability of tunnels has mainly been evaluated based on displacement. Because displacement due to the excavation process is significant, back analysis of the structure and ground can be performed easily. Recently, the length of a segment-lined tunnel
Joon-Sang An +5 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Stress Monitoring of Civil and Mechanical Engineering Infrastructure
, 2007 Structural Integrity Monitoring is a rapidly growing science and practice which promises in the future to measure and record every shudder and twitch within the lifetime of future structural components.
Brennan, Feargal P.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
PLoS ONEMany practitioners, such as pilots, frequently face working memory (WM) demands under acute stress environments, while the effect of acute stress on WM has not been conclusively studied because it is moderated by a variety of factors.
Yaowei Liang +6 more
doaj +1 more source
Microbial Stress: from Systems to Molecules and Back
, 2018 The 2018 EFB fourth Microbial Stress meeting will be hosted in the historic and cosy town of Kinsale, on the south coast of Ireland, not far from the city of Cork.
Daniela De Biase +2 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Heterogeneous materials: a new class of materials with unprecedented mechanical properties
Materials Research Letters, 2017 Here we present a perspective on heterogeneous materials, a new class of materials possessing superior combinations of strength and ductility that are not accessible to their homogeneous counterparts.
Xiaolei Wu, Yuntian Zhu
doaj +1 more source