Results 171 to 180 of about 21,143 (274)

Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
We found an early Sgk1.1 mRNA upregulation within oligodendrocyte‐lineage cells of 5 × FAD mice, implicating SGK1.1 signaling as an early driver of myelin pathology. Mechanistically, SGK1.1 promotes HDAC2 phosphorylation at S422/S424, thereby impairing oligodendrocyte maturation.
Shiji Deng   +13 more
wiley   +1 more source

Notice of Approved Backflow Prevention Assembly & Equipment for South Carolina

open access: yes
Enclosed is the revised list of approved backflow prevention assemblies and a list of backflow equipment ...
South Carolina Department of Environmental Services, Bureau of Water
core   +1 more source

Anterior Cingulate Cortex Astrocytes Regulate Chronic Itch and Comorbid Negative Emotional Disorders in Mice

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
ACC astrocytes are morphologically and functionally activated in DCP‐induced chronic itch. Chemogenetic activation of these astrocytes positively modulates the calcium activity of local CaMKII+ excitatory neurons and the release of D‐serine and ATP, and exerts anti‐pruritic, anxiolytic, and anti‐depressant effects.
Ze Fan   +12 more
wiley   +1 more source

Optimization Study of Valve Closing Schemes for Long‐Distance Gravity Flow Water Supply Systems Based on the NSGA‐II Algorithm

open access: yesEngineering Reports, Volume 8, Issue 9, September 2026.
Taking the Ruyang Water Supply Project of Qianping Reservoir as the research object, a model was built with Bentley Hammer and valve closure schemes were optimized using the NSGA‑II algorithm. Results show that multistage closure is superior to single‑stage, and the optimized three‑stage scheme provides better water hammer protection, offering ...
Ke Wang   +5 more
wiley   +1 more source

Hydrogen‐Enriched Tri‐Fuel Combustion for Low‐Carbon Engines at Medium Engine Load: A Comprehensive CFD Analysis

open access: yesEnergy Science &Engineering, Volume 14, Issue 9, Page 4130-4151, September 2026.
CFD analysis of a diesel–CH4–H2 tri‐fuel engine shows that increasing hydrogen energy share (HES) enhances mixing and accelerates combustion, improving pressure, efficiency, and reducing CO and soot. At 60% HES, ISFC improves 26.2%, soot drops 95%, while NOx increases due to higher temperatures. ABSTRACT The global commitment to achieve net‐zero carbon
Md. Ifthaker Alam   +4 more
wiley   +1 more source

The Branching Projection Pattern of Ventral Subicular Cells Revealing the Complex Integrative Role of Key Hippocampal Outputs in Driving Fear and Anxiety

open access: yesHippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT The ventral regions of the hippocampus play a crucial role in emotional responses through projections to the hypothalamus. In this context, the ventral hippocampus sends extensive projections to components of the medial hypothalamic defensive circuit, where projections to the anterior hypothalamic nucleus (AHN) influence both anxiogenic and ...
Fernando Falkenburger Melleu   +3 more
wiley   +1 more source

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