Results 31 to 40 of about 107,062 (139)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Background subtraction in electron Compton spectroscopy [PDF]

Micron, 2022
Compton scattering in electron energy loss spectroscopy (EELS) is used to quantify the momentum distribution of occupied electronic states in a solid. The Compton signal is a broad feature with a width of several hundred eV. Furthermore, the weak intensity results in a low peak-to-background ratio.
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Independent multimodal background subtraction [PDF]

, 2012
Background subtraction is a common method for detecting moving objects from static cameras able to achieve real-time performance. However, it is highly dependent on a good background model particularly to deal with dynamic scenes. In this paper a novel real-time algorithm for creating a robust and multimodal background model is presented.
BLOISI, Domenico Daniele, IOCCHI, Luca
openaire   +2 more sources

Moving object detection using modified GMM based background subtraction

Measurement: Sensors, 2023
Academics have become increasingly interested in creating cutting-edge technologies to enhance Intelligent Video Surveillance (IVS) performance in terms of accuracy, speed, complexity, and deployment.
S. Rakesh, Nagaratna P. Hegde, M. Venu Gopalachari, D. Jayaram, Bhukya Madhu, Mohd Abdul Hameed, Ramdas Vankdothu, L.K. Suresh Kumar   +7 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Segmentation of Moving Object Using Background Subtraction Method in Complex Environments [PDF]

Radioengineering, 2016
Background subtraction is an extensively used approach to localize the moving object in a video sequence. However, detecting an object under the spatiotemporal behavior of background such as rippling of water, moving curtain and illumination change or ...
S. Kumar, J. S. Yadav
doaj  

FPGA-Based Improved Background Subtraction for Ultra-Low Latency

IEEE Access
In recent years, advancements in telecommunication technology have led to the proliferation of high-speed, large-capacity, low-latency communication. The COVID-19 pandemic has also accelerated the adoption of remote work globally, making real-time remote
Yoshiyuki Oshima, Yoshiki Yamaguchi, Ryohei Tsugami, Toshihito Fujiwara, Tatsuya Fukui, Satoshi Narikawa   +5 more
doaj   +1 more source

Real-Time Implementation Of Moving Object Detection In Video Surveillance Systems Using Fpga

Computer Science, 2011
The article presents the concept of real-time implementation computing tasks in videosurveillance systems. A pipeline implementation of a multimodal background generationalgorithm for colour video stream and a moving objects segmentation based on ...
Tomasz Kryjak, Marek Gorgoń
doaj   +1 more source