Results 121 to 130 of about 197,539 (295)
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Vibration-based methods for structural and machinery fault diagnosis based on nonlinear dynamics tools [PDF]
, 2012 This study explains and demonstrates the utilisation of different nonlinear-dynamics-based procedures for the purposes of structural health monitoring as well as for monitoring of robot ...
Manoach, Emil, Trendafilova, Irina
core
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Effect of Gear Backlash Function on the Dynamics Characteristic of Helical Gear
Jixie chuandong, 2015 A three- degree- of- freedom shaft- torsion coupling nonlinear dynamics model of a single-stage helical cylindrical gear transmission system is established,which included the nonlinear factors such as gear backlash,time- varying stiffness,transmission ...
Wang Xin, Kang Boqiang
doaj
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, EarlyView.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
Calculation of Accurate Meshing Backlash for Cycloidal-pin Wheel Drive in RV Reducer
Jixie chuandong, 2018 The meshing backlash of cycloidal-pin wheel drive in RV reducer is the key factor that affects the transmission performance. At present,the formula method is adopted mainly to calculate the initial meshing backlash of cycloidal-pin wheel.
Yang Jingzhao +5 more
doaj
Frontiers in Bioengineering and BiotechnologyDuring activities of daily living (ADLs), the wrist is mainly engaged in positioning and directing the hand. Researches have demonstrated that restoring wrist mobility can significantly enhance the manipulation ability, reduce body distortion caused by ...
Yang Liu +3 more
doaj +1 more source
Advanced Science, EarlyView.Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang +23 more
wiley +1 more source
A data-driven model for valve stiction [PDF]
, 2003 The presence of nonlinearities, e.g., striction, hysteresis and backlash in a control valve limits the control loop performance. Striction is the most common problem in spring-diaphragm type valves, which are widely used in the process industry.
Choudhury, M.A.A.S. +2 more
core
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source