Results 71 to 80 of about 10,269 (246)

Climate Change and Separation of Powers in European Human Rights Law: Why “KlimaSeniorinnen” has been Met with a Vigorous Separation of Power Criticism

German Law Journal
While the judgement of the European Court of Human Rights (ECtHR) in KlimaSeniorinnen v. Switzerland has been hailed by many as a landmark in climate change and human rights litigation, the response by Switzerland and many intervening parties has been ...
Juan Manuel Klein
doaj   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

El concepto “backlash” en la europa neo-liberal

Revista del CISEN, 2015
Derechos e igualdad de género progresan en una alternancia entre avances y retrocesos. El concepto de “backlash” -contragolpe- elaborado por la feminista norteamericana Susan Faludi en 1991, diez años después de la llegada al poder de los neo ...
Giovanna Campani
doaj  

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Impact of Electrolyte Formulation on the Phase Behavior and Interphase Formation of Sb/Graphite Electrodes for K‐Ion Batteries

Advanced Science, EarlyView.
Electrolyte formulation is shown to govern both interphase chemistry and bulk phase evolution in Sb/graphite anodes for potassium‐ion batteries. A diglyme‐based localized high‐concentration electrolyte promotes a thin inorganic‐rich interphase, suppresses deep graphite potassiation, limits electrode swelling, and stabilizes amorphous KxSb formation ...
Ezzoubair Bendadesse, Max Wacha, Zeynep Erdol, Yanan Sun, Carsten Prinz, Mirko Boin, Manuela Klaus, Tatiana Mishurova, Till Wolfram, Jürgen Janek, Philipp Adelhelm   +10 more
wiley   +1 more source

Research of the Backlash Detection Method of RV40E Precision Reducer

Jixie chuandong, 2020
The bidirectional transmission error method is a dynamic continuous backlash detection method based on transmission error detection. Aiming at the fitting error problem of traditional static hysteretic curve testing RV reducer， an improved hysteretic ...
Zhao Daxing, Qin Yuan, Wu Guiming, Li Xixing, Liu Hongdi   +4 more
doaj  

How Proton Incorporation Reshapes Lattice Dynamics In BaSnO3‐Type Proton Conductors

Advanced Science, EarlyView.
Yttrium‐doped BaSnO3 exhibits isotope‐dependent changes in its low‐energy vibrational density of states upon hydration. Comparison of dry, H2O‐, and D2O‐treated samples re‐veals mass‐dependent phonon renormalization linked to proton dynamics near oxygen va‐cancies, providing experimental insight into hydrogen‐coupled lattice excitations in proton ...
Artur Braun, Alexey Rulev, Nobumoto Nagasawa, Hongxin Wang, Tatyana Bendikov, Vladimir Pomjakushin, Martin Kunz, Yoshitaka Yoda, Qianli Chen, Stephen P. Cramer   +9 more
wiley   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Non-back-drivable clutch based self-locking mechanism of prosthetic joint to improve manipulation stability

Frontiers in Bioengineering and Biotechnology
During activities of daily living (ADLs), the wrist is mainly engaged in positioning and directing the hand. Researches have demonstrated that restoring wrist mobility can significantly enhance the manipulation ability, reduce body distortion caused by ...
Yang Liu, Yuhui Luo, Ting Xiao, Jiejunyi Liang   +3 more
doaj   +1 more source